Adrenal gland tumors linked to ADHD diagnosis

Pediatric patients diagnosed with pheochromocytomas (PHEO) or paragangliomas (PGL) were nearly three times as likely to also carry a diagnosis of attention deficit hyperactivity disorder (ADHD),...
Source: Clinical Endocrinology News - Category: Endocrinology Source Type: news

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(Natural News) When a child is diagnosed with ADHD, or attention-deficit/hyperactivity disorder, medication is often recommended. Profit-minded pharmaceutical companies and doctors hand these drugs out like candy, and some teachers even encourage it in hopes of having placated students who are easier to keep under control. Unfortunately, children often end up paying the price for...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
We report a case of a 73-year-old man with PHEO in whom genetic testing revealed a large pathogenic heterozygous deletion of 1.14 Mb encompassing the entire coding sequence of the NF1 gene while the patient showed no signs of clinical NF1.This case illustrates that the diagnosis of NF1 should not be excluded in patients with PHEO in the absence of clinical diagnosis of the disease and support that older patients with PHEO should also be offered genetic counselling.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Despite the discovery of the oxygen-sensitive regulation of HIFα by the von Hippel–Lindau (VHL) protein, the mechanisms underlying the complex genotype/phenotype correlations in VHL disease remain unknown. Some germline VHL mutations cause familial pheochromocytoma and encode proteins that preserve their ability to down-regulate HIFα. While type 1, 2A, and 2B...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
Publication date: Available online 15 August 2019Source: Life SciencesAuthor(s): Katsuhiko Noguchi, Kimio Sugaya, Saori Nishijima, Mayuko Sakanashi, Katsumi Kadekawa, Katsuhiro Ashitomi, Shiho Okitsu, Hideyuki YamamotoAbstractAimsLigation of the urethra to create partial bladder outlet obstruction has widely been used as an animal model of bladder obstruction, although obstructive bladder dysfunction may be due to both mechanical and functional obstruction. Previous studies in rodents have demonstrated that long-term nitric oxide (NO) deficiency can lead to detrusor overactivity, and lack of NO may thus cause impairment of...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 12 August 2019Source: Life SciencesAuthor(s): Yun-Feng Zhou, Li Feng, Xin-Min Liu, Xue Tao, Li-Sha Wang, Meng-Di Zhang, Zhi Wang, Shan-Guang Chen, Qi ChangAbstractAimsThe present study aims to investigate the impacts of olfactory bulbectomy (OBX) on urinary metabolic profile and tryptophan metabolites in prefrontal cortex (PFC) of rats, and to explore the regulation effects of fluoxetine.Main methodsOBX model was developed by aspiration of olfactory bulbs. After fluoxetine treatment (10 mg/kg) for 14 days, urine samples were collected and behavior tests were applied. Tryptophan (TRP) ...
Source: Life Sciences - Category: Biology Source Type: research
ConclusionOur study supports the notion that NDDs may exist along a complex phenotypic/biological continuum. All NDD groups showed a sustained parietal activity profile suggesting that they share a strong reliance on the posterior parietal cortices to complete the mental flexibility task; future studies could elucidate whether this is due to delayed brain development or compensatory functioning. The differences in frontal activity may play a role in differentiating the NDDs. The OCD group showed sustained prefrontal activity that may be reflective of hyperfrontality. The ASD group showed reduced frontal activation suggesti...
Source: Journal of Neurodevelopmental Disorders - Category: Neurology Source Type: research
Source: ADHD Attention Deficit and Hyperactivity Disorders - Category: Psychiatry Source Type: research
ConclusionsThis study demonstrates that attentional stability is impaired in children with epilepsy and/or ADHD. Bron–Lyon Attention Stability Test seems to be a sensitive test to detect attentional stability deficit in children with epilepsy and with attentional complaints who did not meet all criteria of ADHD.We propose that BLAST could be a useful clinical neuropsychological tool to assess attentional disorders in children.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Pediatric patients diagnosed with pheochromocytomas (PHEO) or paragangliomas (PGL) were nearly three times as likely to also carry a diagnosis of attention deficit hyperactivity disorder (ADHD),...
Source: Clinical Psychiatry News - Category: Psychiatry Source Type: research
Horm Metab ResDOI: 10.1055/s-0042-106725The aim of the study is to evaluate if there is an association between attention deficit hyperactivity disorder (ADHD) and the diagnosis of pheochromocytoma/paraganglioma (PHEO/PGL) in pediatric patients. A case series study of 43 patients under the age of 18 with PHEO/PGL tumors who were evaluated at the National Institute of Health between January 2006 and May 2014 is reported. Prior diagnosis of ADHD and treatment course with stimulant medications was recorded. Patient symptoms, catecholamine and metanephrine levels, tumor characteristics, and genetic analyses for syndromes associ...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Endocrine Care Source Type: research
More News: ADHD | Endocrinology | Hyperactivity | Paraganglioma | Pediatrics | Pheochromocytoma