Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling
Conclusions
We identified Dyrk1a as a novel negative regulator of D-cyclin-mediated Rb/E2f-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy, dose-specific Dyrk1a expression and activity appears to be critical for the hyperplastic and hypertrophic growth of the developing heart.
Source: Cardiovascular Research - Category: Cardiology Authors: Hille, S., Dierck, F., Kühl, C., Sosna, J., Adam-Klages, S., Adam, D., Lüllmann-Rauch, R., Frey, N., Kuhn, C. Tags: Cardiac biology and remodelling Source Type: research
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