Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats

Conclusion
T2D leads to arrhythmogenic atrial remodelling in ZDF rats. CatA-inhibition reduces LA bradykinin-degrading activity in ZDF and suppresses the development of atrial structural changes and AF-promotion, implicating CatA as an important mediator for AF-substrate in T2D.

Source: Cardiovascular Research - May 18, 2016 Category: Cardiology Authors: Linz, D., Hohl, M., Dhein, S., Ruf, S., Reil, J.-C., Kabiri, M., Wohlfart, P., Verheule, S., Böhm, M., Sadowski, T., Schotten, U. Tags: Cardiac biology and remodelling Source Type: research