The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a

Conclusion
We identified Atrap as a novel regulatory protein of the cardiac Ca2+-ATPase SERCA2a. We suggest that Atrap enhances the activity of SERCA2a and, consequently, facilitates ventricular relaxation.

Source: Cardiovascular Research - May 18, 2016 Category: Cardiology Authors: Mederle, K., Gess, B., Pluteanu, F., Plackic, J., Tiefenbach, K.-J., Grill, A., Kockskämper, J., Castrop, H. Tags: Cardiac biology and remodelling Source Type: research