BMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery

Conclusion
The disequilibrium between BMP-7 and TGF-β signals plays a relevant role in the LV remodelling response to haemodynamic stress in TAC mice and AS patients. Our observations may provide new important insights aimed at developing novel therapies designed to prevent, halt, or reverse LV pathological remodelling in pressure overload cardiomyopathy.

Source: Cardiovascular Research - May 18, 2016 Category: Cardiology Authors: Merino, D., Villar, A. V., Garcia, R., Tramullas, M., Ruiz, L., Ribas, C., Cabezudo, S., Nistal, J. F., Hurle, M. A. Tags: Cardiac biology and remodelling Source Type: research