Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice

Conclusion
These findings suggest that circulating or MSC-EXOs may modulate pulmonary hypertensive effects based on their miR cargo. The ability of MSC-EXOs to reverse MCT-PH offers a promising potential target for new PAH therapies.

Source: Cardiovascular Research - May 18, 2016 Category: Cardiology Authors: Aliotta, J. M., Pereira, M., Wen, S., Dooner, M. S., Del Tatto, M., Papa, E., Goldberg, L. R., Baird, G. L., Ventetuolo, C. E., Quesenberry, P. J., Klinger, J. R. Tags: Integrative physiology and pathophysiology Source Type: research