The E119D neuraminidase mutation identified in a multidrug-resistant influenza A(H1N1)pdm09 isolate severely alters viral fitness in vitro and in animal models.

In conclusion, the E119D NA mutation that could emerge in A(H1N1)pdm09 viruses during zanamivir therapy has a significant impact on viral fitness and such mutant is unlikely to be highly transmissible. PMID: 27185624 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/27185624?dopt=Abstract

Source: Antiviral Research - May 12, 2016 Category: Virology Authors: Abed Y, Bouhy X, L'Huillier AG, Rhéaume C, Pizzorno A, Retamal M, Fage C, Dubé K, Joly MH, Beaulieu E, Mallett C, Kaiser L, Boivin G Tags: Antiviral Res Source Type: research