Weight Loss Before Fertility Treatment Didn't Boost Odds of Delivering Healthy Baby Vaginally (FREE)
By Amy Orciari Herman Edited by Susan Sadoughi, MD For obese infertile women, a lifestyle intervention to lose weight before fertility treatment might not increase the chances of delivering a healthy baby vaginally, a New England Journal of Medicine study finds.Nearly 580 infertile Dutch women with BMIs …
CONCLUSION: First line management of infertility once a diagnosis of PCOS is made should include weight loss and exercise with goals to below class 2 obesity (BMI
on JP PMID: 29914911 [PubMed - in process]
Conditions: Male Infertility; Obesity; Weight Loss Interventions: Dietary Supplement: Low Energy Diet; Other: NHS advice on healthy eating Sponsor: Imperial College London Recruiting
Abstract Deficiency of the 21-hydroxylase enzyme is the most common form of congenital adrenal hyperplasia (CAH), accounting for more than 95% of the cases. With the advent of newborn screening and hormone replacement therapy, most children with CAH survive into adulthood. Adolescents and adults with CAH experience a number of complications, including short stature, obesity, infertility, impaired bone mineral density, and reduced quality of life. Transition from pediatric to adult care and management of long-term complications are challenging for both patients and practitioners. In adulthood, the aims of the medic...
Conclusion The TP53 and BRCA1 may constitute an inheritable risk factor for PCOS in South Indian women.
Serum leptin levels are augmented in obese infertile men and in men with azoospermia. They also correlate inversely with sperm concentration, motility and normal forms. The mechanisms underlying the adverse ef...
CONCLUSIONS: Exogenous leptin negatively affects sperm parameters and impairs blood testis barrier integrity in mice. Leptin reduced tight junction-associated proteins in Sertoli cells, indicating that leptin has a direct role in impairing blood testis barrier integrity. Given the function of blood testis barrier in maintaining normal spermatogenesis, leptin-induced blood testis barrier impairment may be one of the mechanisms contributing to male subfertility and infertility. PMID: 29855380 [PubMed - in process]
Polycystic Ovary Syndrome (PCOS) is a heterogeneous multifactorial endocrine metabolic disorder. In addition to hyperandrogenism, acne, hirsutism, obesity, oligoanovulation and infertility, insulin resistance is also a common feature in women of PCOS. Tumor suppressor genes (TSGs) perform essential function in the maintenance of genomic stability and regulatory pathways influencing the activity of several replication and transcription factors. The main aim of this study was to investigate the association of Single Nucleotide Polymorphisms of TP53, BRCA1and BRCA2 genes with the susceptibility to PCOS in South Indian women.
Conclusions Women being treated for infertility may wish to participate in initiatives that promote fertility. Training, adopting healthy lifestyle behaviours and perceptions of self-efficacy can be improved.