Staying a step ahead of cancer

Scientists have designed a potential cancer therapy that uses a unique strategy to block mTOR, a molecule that helps drive the growth of many tumors. In animal experiments, the drug reduces the size of tumors that are resistant to earlier-generation mTOR inhibitors.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer. Mol Med Rep. 2019 Mar 14;: Authors: Cai F, Cai L, Zhou Z, Pan X, Wang M, Chen S, Luis MAF, Cen C, Biskup E Abstract Transcription intermediary factor 1γ (Tif1γ), a ubiquitous nuclear protein, is a regulator of transforming growth factor‑β (TGF‑β)/Smad signaling. Tif1γ can function as an oncogene and as a tumor suppressor. In the present study, Tif1γ levels were measured in the plasma of patients with breast cancer in order to investigate the association of Tif1&gam...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
ConclusionsAnalysis of the constructed pharmacological networks results allowed for the prediction and interpretation of the multi multi-constituent, multi-target, and multi-pathway mechanisms of North African plants as potential source for supportive treatment of cancer where their potential molecular mechanism towards cancer-associated targets, biological processes and pathways were revealed.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 31 October 2017Source: Seminars in Cancer BiologyAuthor(s): Sergey G. Klochkov, Margarita E. Neganova, Nagendra Sastry Yarla, Madhukiran Parvathaneni, Bechan Sharma, Vadim V. Tarasov, George Barreto, Sergey O. Bachurin, Ghulam Md Ashraf, Gjumrakch AlievAbstractRas proteins have been reported to play key role in oncologic diseases. Ras proteins are associated with cellular membranes for its carcinogenic activities through post-translational modifications, including farnesylation. Farnesyltransferase is responsible for a type of Ras membrane targeting, which leads to cancer origin and progr...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 6 October 2017Source: Seminars in Cancer BiologyAuthor(s): Yinnan Chen, Hongmei Zhang, Yanmin ZhangAbstractEph receptors and their Eph receptor-interacting (ephrin) ligands together form an important cell communication system with diverse roles. Experimental evidence demonstrated Eph receptor bidirectional signaling with both tumor-suppressing and tumor-promoting activities in cancer cells. The tyrosine kinase EphB4, a member of the Eph receptor family, has been associated with tumor angiogenesis, growth and metastasis, thus making it a valuable and attractive target for drug design for t...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 11 September 2017Source: Seminars in Cancer BiologyAuthor(s): Ilaria Peluso, Nagendra Sastry Yarla, Roberto Ambra, Gianni Pastore, George PerryAbstractThe mitogen-activated protein kinases (MAPKs) are fundamental in inflammation and cancer control, through the crosstalk between the redox regulated nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-kB (NFκB) gene expression. MAPKs regulate various cellular activities involved in cancer progression, including proliferation, apoptosis and immune escape and blockade of upstream kinases is a current therapeutic strategy. Howeve...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 21 March 2019Source: European Polymer JournalAuthor(s): Aliyeh Ghamkhari, Farideh Mahmoodzadeh, Marjan Ghorbani, Hamed HamishehkarAbstractGold nanoparticles have been used for centuries in medicine for clinical procedures. In this context, gold nanorods are considered as very promising in cancer therapy. For this purpose, gold nanorods (GNRs) coated by stimuli-responsive thiol-end capped ABC triblock copolymer [poly (metacrylic acid)-block-poly (N-isopropylacrylamide)-block-poly (N,N-dimethylaminoethyl methacrylate)-SH; P(MAAc-b-NiPAAM-b-DMAEMA)-SH] for intracellular delivery of doxorubic...
Source: European Polymer Journal - Category: Chemistry Source Type: research
In this study, we reported a dual HDAC and DNMT inhibitor 208 and found it induced G1 cell cycle arrest and apoptosis in U937 cells. Proteome and bioinformatic analyses revealed that the combined inhibition of DNMT1 and HDAC by 208 affected the expression of a series of proteins involved in many biological processes. We observed that several proteins associated with G1 cell cycle arrest and apoptosis were down regulated after 208 treatment, including p85α, MEK, and CDK4, suggesting that 208 induces cell cycle arrest and apoptosis through the p85α/MEK-mediated pathway in U937 cells. Moreover, biological function...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
This study investigated the impact of immune-related pathway inhibition, among them indolamine 2,3-dioxygenase (IDO), alone and together with immune cells on growth and viability of colorectal cancer (CRC) cells. A panel of patient-derived CRC cell lines with different molecular characteristics (CpG island methylator phenotype, chromosomal, and microsatellite instability) was included. Initial phenotyping of CRC cell lines (n=17) revealed high abundance of immunosuppressive checkpoint-molecules in general, but an individual profile for IDO. Presence of immune-related molecules was independent of the molecular subtype. Sele...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In conclusion, it is supposed that nano-encapsulation of MET into polymeric PLGA-PEG NPs may be a convenient drug delivery system to enhance its anticancer effects for ovarian cancer therapy. PMID: 30892093 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Experts shared the challenges they've encountered in integrating novel treatments such as CAR T-cell therapy into practice at the 2019 NCCN Annual Conference.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
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