Staying a step ahead of cancer

Scientists have designed a potential cancer therapy that uses a unique strategy to block mTOR, a molecule that helps drive the growth of many tumors. In animal experiments, the drug reduces the size of tumors that are resistant to earlier-generation mTOR inhibitors.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Erik W. J. Mollen, Jonathan Ient, Vivianne C. G. Tjan-Heijnen, Liesbeth J. Boersma, Lucio Miele, Marjolein L. Smidt, Marc A. G. G. Vooijs
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Aryl hydrocarbon receptor ligand 5F 203 induces the expression of putative tumor suppressor cytoglobin (CYGB) and promotes anticancer activity and apoptosis in vivo and in vitro. CYGB promotes 5F 203 –mediated cell death, caspase‐3/‐7 activation, proapoptotic gene expression, lysosomal membrane permeabilization (LMP), and cathepsin B release in triple negative breast cancer (TNBC) cells. These findings suggest that AhR ligands such as 5F 203 upregulate CYGB to confer TNBC cell death. AbstractNearly 40 000 women die annually from breast cancer in the United States. Clinically available targeted breast cancer thera...
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
Publication date: Available online 16 November 2018Source: Pharmacological ResearchAuthor(s): Jan Skoda, Karolina Borankova, Patric J. Jansson, Michael L.-H. Huang, Renata Veselska, Des R. RichardsonAbstractMitochondria play vital roles in various cellular processes, ranging from cellular metabolism to signal transduction and cell death regulation. As these properties are critical for cancer growth, the mitochondrion has recently become an attractive target for anti-cancer therapies. In addition, it has come to light that mitochondria are crucially involved in the regulation of stem cell identity, differentiation and fate....
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Authors: Di C, Zhang Q, Wang Y, Wang F, Chen Y, Gan L, Zhou R, Sun C, Li H, Zhang X, Yang H, Zhang H Abstract Exosomes are nanoscale vesicles shed from all cell types and play a major role in communication and transportation of materials between cells due to their ability to transfer proteins and nucleic acids from one cell to another. Analogous in size and function to synthetic nanoparticles, exosomes offer many advantages, rendering them the most promising candidates for targeted drug or gene delivery vehicles. Exosomes can also induce chemoresistance or radioresistance of tumor cells. Studies about the related m...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Abstract Manipulating the assembly of gold nanoparticles (AuNPs) for maximizing the photothermal effect is a promising strategy for cancer therapy. Herein, taking advantage of the well-known tetrazole/alkene photo-click chemistry, we for the first time demonstrated that small AuNPs (23 nm) decorated with both 2, 5-diphenyltetrazole and methacrylic acid on the surface could form covalently cross-linked aggregates upon laser irradiation (λ = 405 nm). The in vitro studies indicated that the light-triggered assembling remarkably shifted the surface plasmon resonance of AuNPs to near-infrared (NIR) regions, whic...
Source: Chembiochem - Category: Biochemistry Authors: Tags: Chembiochem Source Type: research
Publication date: Available online 15 November 2018Source: Saudi Journal of Biological SciencesAuthor(s): Yong Cao, Fei Dai, Yanmei Li, Lu Jia, Yunpeng Luan, Youjie ZhaoAbstractThe roots of Codonopis bulleynana Forest ex diels (cbFed), locally known as Tsoong, have been used as a tonic food. Tsoong has wide range of pharmacological effects, including anticancer effects. In the present study, the anticancer activity of Tsoong and its potential molecular mechanisms were investigated. Using high throughput sequencing the apoptotic pathway was ranked as one of the most important pathways and the differential expressions of apo...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 16 November 2018Source: Nano TodayAuthor(s): Homan Kang, Shuang Hu, Mi Hyeon Cho, Suk Ho Hong, Yongdoo Choi, Hak Soo ChoiAbstractNanomaterials have revolutionized cancer imaging, diagnosis, and treatment. Multifunctional nanoparticles in particular have been designed for targeted cancer therapy by modulating their physicochemical properties to be delivered to the target and activated by internal and/or external stimuli. This review will focus on the fundamental “chemical” design considerations of stimuli-responsive nanosystems to achieve favorable tumor targeting beyond biolog...
Source: Nano Today - Category: Nanotechnology Source Type: research
Publication date: 15 November 2018Source: Cell, Volume 175, Issue 5Author(s): Matthew M. Gubin, Ekaterina Esaulova, Jeffrey P. Ward, Olga N. Malkova, Daniele Runci, Pamela Wong, Takuro Noguchi, Cora D. Arthur, Wei Meng, Elise Alspach, Ruan F.V. Medrano, Catrina Fronick, Michael Fehlings, Evan W. Newell, Robert S. Fulton, Kathleen C.F. Sheehan, Stephen T. Oh, Robert D. Schreiber, Maxim N. Artyomov
Source: Cell - Category: Cytology Source Type: research
Abstract Self-hardening calcium phosphate cements present ideal bone tissue substitutes from the standpoints of bioactivity and biocompatibility, yet they suffer from (a) weak mechanical properties, (b) negligible osteoinduction without the use of exogenous growth factors, and (c) a lack of intrinsic antibacterial activity. Here we attempt to improve on these deficiencies by studying the properties of self-setting Fe-doped bone-integrative cements containing two different concentrations of the dopant: 0.49 and 1.09 wt% Fe. The hardening process, which involved the transformation of Fe-doped β-tricalcium pho...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00189
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
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