Penis transplant: welcome to the frontier of a fascinating science | Celine Gounder

Transplant medicine has overcome problems of infection, rejection and surgical complexity. Now we just need more people to become donorsThe first penile transplant in the US was performed on cancer survivor Thomas Manning at Harvard’s Massachusetts General Hospital last week. This paves the way for the treatment of other cancer patients, wounded veterans, burn victims and all those who’ve suffered genital trauma or needed radical surgery to save their lives. Transplanting a penis is technically much simpler than transplanting a lung or liver, so why did it take this long?Transplant medicine is much older than many realize. Over 3,000 years ago, the ancient Indian physician Sushruta used skin transplants – more commonly today called grafts – to reconstruct noses amputated as punishment for crimes. As early as the 1600s, patients were treated with animal blood infusions or bone transplants. But early transplant medicine was thwarted by infections and the immune system. Our skin is one of our most basic defenses – acting like the high walls and moat of a medieval city – guarding us against invasion by all sorts of microbes in the environment. An appreciation of the germ theory and the need for antisepsis – at first with carbolic acid, a corrosive chemical that burns, bleaches and numbs the skin and is poisonous to the lungs if inhaled – helped bring down surgical death rates dramatically. Anesthesia made it possible to undertake lo...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Health Science Society US news World news Medical research Source Type: news

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In this study, we use ChIP-Seq to identify Dppa4 binding genome-wide in three distinct cell types: mouse embryonic stem cells (mESC), embryonal carcinoma cells, and 3T3 fibroblasts ectopically expressing Dppa4. We find a core set of Dppa4 binding sites shared across cell types, and also a substantial number of sites unique to each cell type. Across cell types Dppa4 shows a preference for binding to regions with active chromatin signatures, and can influence chromatin modifications at target genes. In 3T3 fibroblasts with enforced Dppa4 expression, Dppa4 represses the cell cycle inhibitor Cdkn2c and activates Ets family tra...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Conclusions: LUCAT1 was upregulated in ccRCC tissues and renal cancer cell lines, and significantly correlated with malignant stage and poor prognosis in ccRCC. LUCAT1 promoted proliferation and invasion in ccRCC cells through the AKT/GSK-3 β signaling pathway. We also revealed that LUCAT1 overexpression was induced by chemokine CXCL2. These findings indicate that the CXCL2/LUCAT1/AKT/GSK-3β axis is a potential therapeutic target and molecular biomarker for ccRCC.Cell Physiol Biochem 2018;48:891 –904
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Conclusions: The findings of the current study indicated that the overexpression of galectin-1 promoted the activation of HSCs, which reduced the inflammatory response by exerting immunosuppressive effects and accordingly contributed to immune tolerance in LT.Cell Physiol Biochem 2018;48:863 –879
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Conclusion: ILND is burned by a high complication rate. VEIL provides a less invasive approach and a saphenous-sparing technique ensures a lower complication rate, reducing lymphorrhea, skin necrosis and wound complications (1 – 3). In experienced laparoscopic hands, VEIL is a safe and effective treatment.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Conclusion: ILND is burned by a high complication rate. VEIL provides a less invasive approach and a saphenous-sparing technique ensures a lower complication rate, reducing lymphorrhea, skin necrosis and wound complications (1 – 3). In experienced laparoscopic hands, VEIL is a safe and effective treatment.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Conclusion: ILND is burned by a high complication rate. VEIL provides a less invasive approach and a saphenous-sparing technique ensures a lower complication rate, reducing lymphorrhea, skin necrosis and wound complications (1 – 3). In experienced laparoscopic hands, VEIL is a safe and effective treatment.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Olympic athletes have a secret that most mere mortals just don't get. And it's the same secret that can make you a gold-medal superstar in bed.  I'm talking about oxygen.  Olympians understand that every cell in your body is designed to burn oxygen. Cut back on oxygen and all cellular processes slow down. You start to become tired or short of breath. So, high concentrations of oxygen in every cell in your body makes the difference between a gold medal and an "also ran."  It's the same for you in just about every part of your life. With plenty of oxygen, your body pulses with energy....
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Anti-Aging Source Type: news
Conclusion Vaccine companies have regularly used blood and body parts from killed cows, dogs, worms, mice, chickens, human babies, monkeys, guinea pigs, rabbits, hamsters, rats, etc., to make these vaccines, so using foreskin from newborn babies may not surprise some. For many, it is appalling. [28] Circumcisions fuel multi-billion dollar industries. If you see neonatal foreskin for sale, which is very easy to find on the internet, remember that these newborn children didn’t consent to being circumcised and they didn’t consent for their foreskin to be sold, used for research purposes, or to be injected into the...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Augustina Ursino Top Stories circumcision truth about vaccines Source Type: blogs
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
BOSTON (CBS) – The man who received the nation’s first penis transplant at Mass General Hospital in Boston wants everyone to know how grateful he is. Tom Manning isn’t hiding. There are no taboos. Manning is eager to tell people about his experience in honest terms, sharing the story of this life-changing medical breakthrough that he had been hoping for years could become a reality. “When my surgeon operated on me, some of the first words out of my mouth were, ‘When am I going to get my transplant?’” Manning told WBZ-TV’s Lisa Hughes. “I just thought, if you can replace...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Seen On WBZ-TV Syndicated Local Watch Listen Lisa Hughes Mass General penis transplant Thomas Manning Source Type: news
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