Infertility risk posed by endometriosis may be half of previous estimation

The infertility risk posed by endometriosis is about half previous estimates and indicates a possible detection bias in earlier studies, according to a new report.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Abstract A mounting body of the literature suggests that environmental chemicals found in food and water could affect female reproduction. Many worldwide daily-used products have been shown to contain chemicals that could incur adverse reproductive outcomes in the perinatal/neonatal periods, childhood, adolescence, and even adulthood. The potential impact of Bisphenol A (BPA), Phthalates and Perfluoroalkyl substances (PFAS) on female reproduction, in particular on puberty, PCOS pathogenesis, infertility, ovarian function, endometriosis, and recurrent pregnancy loss, in both humans and animals, will be discussed in...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
Whole exome sequencing identifies hemizygous deletions in the UGT2B28 and USP17L2 genes in a three‑generation family with endometriosis. Mol Med Rep. 2019 Jan 03;: Authors: Albertsen HM, Matalliotaki C, Matalliotakis M, Zervou MI, Matalliotakis I, Spandidos DA, Chettier R, Ward K, Goulielmos GN Abstract Endometriosis is an enigmatic condition with an unknown etiology and a poorly understood pathogenesis. It is considered to appear from the interplay of many genetic and environmental factors, affecting up to 10% of women and represents a major cause of pain and infertility. The familial association of...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
ABSTRACT Introduction: Endometriosis is a chronic gynecological condition characterized by the presence of endometrial tissue in locations outside the uterus. Its symptoms include dysmenorrhea, dyspareunia, chronic pelvic pain, infertility, dysuria, and dyschezia. Several studies have related the vascular endothelial growth factor (VEGF) gene polymorphisms as a factor for the development of endometriosis. Objectives: The aim of this study was to compare the frequency of the VEGF gene polymorphism rs35569394 in women with endometriosis and a control group, as well as to investigate the association of this polymorphism with ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
ConclusionWe conclude that the prevalence of infertility in China is high, but the uptake of treatment was relatively low.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
South Korea and US teams say infertility could be linked to deficiency of a protein in wombA new study has cast light on why some women with endometriosis experience infertility, with scientists saying the finding could lead to new treatment options.Endometriosis is an inflammatory condition in which cells that usually form the lining of the uterus are present elsewhere, such as the ovaries, fallopian tubes, pelvis and rectum.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Endometriosis Fertility problems Animal experimentation Medical research Pregnancy Health Science Society Lena Dunham Whoopi Goldberg World news Source Type: news
Researchers say infertility in sufferers could be linked to deficiency of protein in wombA new study has cast light on why some women with endometriosis experience infertility, with scientists saying the finding may lead to new treatment options.Endometriosis is an inflammatory condition in which cells that usually form the lining of the uterus are present elsewhere, such as the ovaries, fallopian tubes, pelvis and rectum.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Endometriosis Medical research Society Lena Dunham Whoopi Goldberg Health World news Science Source Type: news
AbstractSome studies have suggested that infertility is a risk factor for endometrial, ovarian and breast cancer. The study aimed to create a comprehensive picture of the association between infertility and the risk of ovarian, endometrial and breast cancer, and whether any association could be explained by ovulatory disturbances, endometriosis or nulliparity. In a population-based cohort of 2,882,847 women, cox regression analysis was used to investigate cancer incidence among infertile women. Overall, infertility was associated with a higher incidence rate of ovarian (adjusted hazard ratio [aHR] 1.53, 95% confidence inte...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus and causes chronic pelvic pain and infertility. However, the exact mechanisms of the pathogenesis of endometriosis-associated infertility are unknown. Epigenetic dysregulation has recently been implicated in infertility. Here, we report a reduction of histone deacetylase 3 (HDAC3) protein amounts in eutopic endometrium of infertile women with endometriosis compared to a control group. To investigate the effect of HDAC3 loss in the uterus, we generated mice with conditional ablation of Hdac3 in progesterone receptor (PG...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
ConclusionsThis study demonstrate that there is an association between hrHPV infections in the UGT with infertility, particularly with endometriosis. It also show a possible continuum hrHPV infection, from LGT to UGT. It suggest future larger studies that could fully investigate the role of hrHPV as an eventual cause of endometriosis and infertility.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Endometriosis can have a profound impact on women ’s lives, including associated pain, infertility, decreased quality of life, and interference with daily life, relationships, and livelihood. The first step in alleviating these adverse sequelae is to diagnose the underlying condition. For many women, the journey to endometriosis diagnosis is long and fraught with barriers and misdiagnoses. Inherent challenges include a gold standard based on an invasive surgical procedure (laparoscopy) and diverse symptomatology, contributing to the well-established delay of 4 to 11 years from first symptom onset to surgical diagnosis.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Call to Action Source Type: research
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