Glomerular disease: MDM2 — a novel target in glomerulonephritis

Nature Reviews Nephrology 12, 316 (2016). doi:10.1038/nrneph.2016.64 Author: Jessica K. Edwards Murine double minute 2 (MDM2) is an E3 ubiquitin ligase involved in NF-κB signalling and negatively regulates TP53-mediated cell cycle arrest and cell death. Now, a new study shows that blockade of MDM2 with nutlin-3a can ameliorate crescentic glomerulonephritis, and MDM2 inhibition in Trp53
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research