Surveillance and Response to Seasonal and Pandemic Influenza by Regional Offices of the World Health Organization

Funding Opportunity Number: CDC-RFA-IP16-1606 Opportunity Category: DiscretionaryFunding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCFDA Number: 93.318Eligible Applicants Others (see text field entitled "Additional Information on Eligibility" for clarification)Agency Name: HHS-CDC-NCIRDClosing Date: Jul 18, 2016Award Ceiling: $2,000,000Expected Number of Awards: 6Creation Date: May 17, 2016Funding Opportunity Description: CDC-RFA-IP16-1606 will support Regional Offices of the World Health Organization, to implement a coordinated plan to assist national governments and regional authorities to improve surveillance for influenza by enhancing capacity for laboratory and epidemiologic surveillance of seasonal and pandemic influenza; to assist the development of simple methods to determine burden of influenza disease in countries and regionally using surveillance data and other routinely collected information; to detect and respond to outbreaks of novel influenza viruses with pandemic potential, such as highly pathogenic avian influenza or swine viruses; and, to assist countries to conduct activities that inform policies on introduction and increased use of influenza vaccines.
Source: Grants.gov - Category: Research Tags: Health Source Type: funding

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We read with interest the recent communication by Guo et al. concerning avian influenza virus pathogenicity.1 Swine has been considered an intermediate host for avian influenza viruses to adapt to humans. Cross-species transmissions caused by novel reassortant swine-originate influenza A virus (S-OIV) are of particular concern after the 2009 pandemic caused by pdH1N1 virus and epidemic outbreaks caused by H3N2v.2,3 The genesis of these viruses shows that reassortant is the major driving force for producing highly infectious variants.
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research
Jennifer M. Rudd1, Sivasami Pulavendran1, Harshini K. Ashar1, Jerry W. Ritchey1, Timothy A. Snider1, Jerry R. Malayer1, Montelongo Marie1, Vincent T. K. Chow2 and Teluguakula Narasaraju1* 1Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, United States2Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore Exaggerated host innate immune responses have been implicated in severe influenza pneumonia. We have previously demonstrated that excessive neutrophils recruited during in...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
We refer transmission of infections in India which have implications for Pakistan [1]. As compared to Pakistan, the range and burden of infectious diseases are enormous in India including Severe Acute Respiratory Syndrome (SARS) contagion in 2002 –2003, Influenza A virus epidemic of 2006 (avian influenza), 2007 Equine influenza, Swine flu pandemic outbreaks in 2009 and 2014 [2]. Moreover, episodes of infectious diseases continue to rise in India, with a recent surge of chikungunya and dengue cases in 2016 [1].
Source: Travel Medicine and Infectious Disease - Category: Infectious Diseases Authors: Source Type: research
Publication date: 1 September 2018Source: Preventive Veterinary Medicine, Volume 157Author(s): Sébastien Grech-Angelini, Séverine Hervé, Nicolas Rose, Nicolas Barbier, François Casabianca, Oscar Maestrini, Alessandra Falchi, Gaëlle SimonAbstractCorsica is a mountainous French island in the north-western Mediterranean Sea. It is a rural area, where pig farming is a major economic activity. Although no acute respiratory outbreaks due to swine influenza A viruses (swIAVs) have ever been reported in this free-ranging pig breeding system, influenza A viruses (IAVs) could be circulating within th...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
100 years have passed since the first well documented influenza pandemic of the 20th century. Today, the majority of the influenza virus burden is known to be caused by two main types of influenza virus —type A and type B. Human influenza A viruses generally stem from birds and swine, whereas influenza B viruses do not have a known animal reservoir, and simply circulate among human beings. Although pandemics occur unexpectedly, these outbreaks are theorised to emerge after a lengthy reassortment process, and not from the direct introduction of an avian virus into human beings.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research
Publication date: 1 August 2017 Source:Cell Reports, Volume 20, Issue 5 Author(s): Hao Song, Jianxun Qi, Haixia Xiao, Yuhai Bi, Wei Zhang, Ying Xu, Fei Wang, Yi Shi, George F. Gao Low-pathogenicity avian influenza viruses (LPAIVs) have caused a global concern to public health since the first novel LPAIV H7N9 outbreak occurred. The receptor-binding properties of the viral hemagglutinin are one key factor for efficient transmission and infection in humans. Recent evidence shows that H4 subtype viruses have been widely circulating in domestic poultry and human asymptomatic infections might have occurred. Here, we evaluated t...
Source: Cell Reports - Category: Cytology Source Type: research
Conclusion This laboratory study analysed an H7N9 strain of bird flu. Researchers wanted to explore whether a particular change to the surface proteins of a virus was capable of allowing the strain to bind to human tissue. This would theoretically lead to human-to-human transmission of the flu virus. It is worth noting that this ability to attach to human cells does not necessarily mean a mutated bird flu virus will be able to infect, replicate and transmit between humans. Other changes would also be required. However, they were unable to further investigate whether this surface change could lead to human-to-human transmis...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news
AbstractIn recent years multiple novel influenza A strains have emerged in humans. We reviewed publically available data to summarise epidemiological characteristics of distinct avian influenza viruses known to cause human infection and describe changes over time. Most recently identified zoonotic strains have emerged in China (H7N9, H5N6, H10N8) – these strains have occurred mostly in association with visiting a live bird market. Most zoonotic AIVs and swine influenza variants typically cause mild infections in humans however severe illness and fatalities are associated with zoonotic H5N6, H10N8, H7N9 and H5N1 serot...
Source: Archives of Public Health - Category: Global & Universal Source Type: research
Conclusion This modelling study shows how the strains of influenza A – "bird flu" – circulating when a person is born give them lifelong protection against new subtypes with the same H protein groups. The researchers call this immune imprinting. This may help to explain the high severity and mortality rate seen among certain groups. For example, the massive flu pandemic of 1918 was an H1N1 strain. This had a very high fatality rate among young adults, which the researchers consider may have been because when they were born (between 1880 and 1900), H3 was the dominant strain. Therefore they had no prot...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news
Publication date: Available online 7 September 2016 Source:Veterinary Microbiology Author(s): Maria Serena Beato, Luca Tassoni, Adelaide Milani, Annalisa Salviato, Guido Di Martino, Monica Mion, Lebana Bonfanti, Isabella Monne, Simon James Watson, Alice Fusaro In August 2012 repeated respiratory outbreaks caused by swine influenza A virus (swIAV) were registered for a whole year in a breeding farm in northeast Italy that supplied piglets for fattening. The virus, initially characterized in the farm, was a reassortant Eurasian avian-like H1N1 (H1avN1) genotype, containing a haemagglutinin segment derived from the pandemic ...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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