Dad's age, diet and lifestyle may cause birth defects
Conclusion This narrative review summarises past research on DNA changes that may occur as a result of a father's age and exposures that could be passed on to his children. In particular, the review discusses animal and human studies that have linked changes in offspring with increasing paternal age, stress and substance use. But this review must largely be considered to only be an opinion piece. We don't know how the researchers identified, appraised and selected the studies they discussed. As such, there is a strong possibility that not all animal and human research relevant to the issue of paternal epigenetic inheritance will have been reviewed and discussed here. There are also no clear methods or results provided for the studies that are discussed, with only a few brief sentences given for each study. We are not able to critique the quality and strength of evidence linking a father's age or any other exposure with the outcome reported. For example, people would likely be concerned by reports that increased rates of autism or congenital defects have been observed in children born to fathers over the age of 40. But we have nothing more to go on than this – no firm risk figures are given. And the observational studies themselves are likely to have been influenced by various unknown sources of bias and confounding, like the report that three-quarters of babies with foetal alcohol syndrome have a father with alcohol use problems....
Publication date: Available online 31 March 2020Source: Materials Today: ProceedingsAuthor(s): K. Senthil Kannan, S. Gayathri Devi, Prithiviraj Nagarajan, G. Flora, R. Ranadevan
Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Yue Zhang, Guoping Liu, Teng Guo, Xiaoyi G. Liang, Heng Du, Lin Yang, Aparna Bhaduri, Xiaosu Li, Zhejun Xu, Zhuangzhi Zhang, Zhenmeiyu Li, Miao He, Jeremiah Tsyporin, Arnold R. Kriegstein, John L. Rubenstein, Zhengang Yang, Bin Chen
Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Sneha Shah, Gemma Molinaro, Botao Liu, Ruijia Wang, Kimberly M. Huber, Joel D. Richter
If you need alcohol treatment while practicing physical distancing, there are several professionally led treatment and mutual-support group options available to you:Professionally led treatmentMany healthcare professionals and programs have offered telehealth alcohol treatment for years. These are phone or video sessions for talk therapy or medical care. Now, with the COVID-19 emergency, more providers are offering telehealth services. Medicare and other insurers are expanding coverage of telehealth services as well. Check with your insurance company about coverage.
Authors: Keenan R, Chepulis L, Ly J, Carter S, Lao C, Asim M, Bhat A, Deo S, Lim KP, Mohammed R, Scarlet S, Lawrenson R Abstract INTRODUCTION Life expectancy in patients with schizophrenia is 15-20 years less than the general population. A dominant cause of morbidity and mortality in these patients is cardiovascular disease. Adverse consequences of modifiable cardiovascular risk factors can be reduced by regular monitoring of metabolic outcomes and intervention if required. AIM To evaluate the metabolic screening in primary care for patients with schizoaffective disorders managed in primary care. To show the useful...
CONCLUSION: Our results indicated that MSC-secretome had DPP-IV/CD26 and APN/CD13 activity. The DPP-IV/CD26 activity was decreased following stimulation of MSCs by toll-like receptor 4 agonist. Further studies are needed to reveal the possible contribution of DPP-IV/CD26 and APN/CD13 in the anti-inflammatory functions of MSC-CM. PMID: 32224540 [PubMed - in process]
Publication date: Available online 1 April 2020Source: Catalysis CommunicationsAuthor(s): Chaoyang Fan, Ruiyi Wang, Peng Kong, Xiaoyu Wang, Jie Wang, Xiaochao Zhang, Zhanfeng Zheng
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ00959H, PaperKai Sheng, baoqian ji, Lei Feng, Yanmin Su, Marko Jagodic, Zvonko Jaglicic, Di Sun The reaction of one equivalent of 1,2-bis-(3,5-dimethylpyrazol-1-yl)-ethane-1,2-diol (H2bdped) with two equivalents of Ni(OAc)2 •4H2O afforded a hexanuclear nickel(II) cluster [Ni6(bdped)2(OAc)8(H2O)4]•6EtOH (SD/Ni6a). The single-crystal X-ray diffraction (SCXRD) structural analysis reveals the one-dimensional... The content of this RSS Feed (c) The Royal Society of Chemistry
Proportion is far higher than those found in clinical trials of the cancer drugs; study finds differences by cancer type.Medscape Medical News
Purpose of review Chronic kidney disease (CKD) is a pervasive and growing health concern that has a significant impact on mortality and morbidity, putting stress on global healthcare systems. CKD affects ∼14% of general populations and ∼36% of high-risk populations and is projected to rise in the coming decade due to increasing rates of diabetes and hypertension. Recent findings Screen, triage, and treat programs aim to detect early stage disease with the intention of promoting medical and lifestyle interventions in line with a patient's level of risk that may slow disease progression and reduce morbidity and ...
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