Dad's age, diet and lifestyle may cause birth defects

Conclusion This narrative review summarises past research on DNA changes that may occur as a result of a father's age and exposures that could be passed on to his children. In particular, the review discusses animal and human studies that have linked changes in offspring with increasing paternal age, stress and substance use.   But this review must largely be considered to only be an opinion piece. We don't know how the researchers identified, appraised and selected the studies they discussed. As such, there is a strong possibility that not all animal and human research relevant to the issue of paternal epigenetic inheritance will have been reviewed and discussed here.   There are also no clear methods or results provided for the studies that are discussed, with only a few brief sentences given for each study. We are not able to critique the quality and strength of evidence linking a father's age or any other exposure with the outcome reported.  For example, people would likely be concerned by reports that increased rates of autism or congenital defects have been observed in children born to fathers over the age of 40. But we have nothing more to go on than this – no firm risk figures are given. And the observational studies themselves are likely to have been influenced by various unknown sources of bias and confounding, like the report that three-quarters of babies with foetal alcohol syndrome have a father with alcohol use problems....
Source: NHS News Feed - Category: Consumer Health News Tags: Genetics/stem cells Food/diet Lifestyle/exercise Pregnancy/child Source Type: news

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Publication date: Available online 31 March 2020Source: Materials Today: ProceedingsAuthor(s): K. Senthil Kannan, S. Gayathri Devi, Prithiviraj Nagarajan, G. Flora, R. Ranadevan
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
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Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Sneha Shah, Gemma Molinaro, Botao Liu, Ruijia Wang, Kimberly M. Huber, Joel D. Richter
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If you need alcohol treatment while practicing physical distancing, there are several professionally led treatment and mutual-support group options available to you:Professionally led treatmentMany healthcare professionals and programs have offered telehealth alcohol treatment for years. These are phone or video sessions for talk therapy or medical care.  Now, with the COVID-19 emergency, more providers are offering telehealth services. Medicare and other insurers are expanding coverage of telehealth services as well. Check with your insurance company about coverage.
Source: NIAAA News - Category: Addiction Authors: Source Type: news
Authors: Keenan R, Chepulis L, Ly J, Carter S, Lao C, Asim M, Bhat A, Deo S, Lim KP, Mohammed R, Scarlet S, Lawrenson R Abstract INTRODUCTION Life expectancy in patients with schizophrenia is 15-20 years less than the general population. A dominant cause of morbidity and mortality in these patients is cardiovascular disease. Adverse consequences of modifiable cardiovascular risk factors can be reduced by regular monitoring of metabolic outcomes and intervention if required. AIM To evaluate the metabolic screening in primary care for patients with schizoaffective disorders managed in primary care. To show the useful...
Source: Journal of Primary Health Care - Category: Primary Care Tags: J Prim Health Care Source Type: research
CONCLUSION: Our results indicated that MSC-secretome had DPP-IV/CD26 and APN/CD13 activity. The DPP-IV/CD26 activity was decreased following stimulation of MSCs by toll-like receptor 4 agonist. Further studies are needed to reveal the possible contribution of DPP-IV/CD26 and APN/CD13 in the anti-inflammatory functions of MSC-CM. PMID: 32224540 [PubMed - in process]
Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
Publication date: Available online 1 April 2020Source: Catalysis CommunicationsAuthor(s): Chaoyang Fan, Ruiyi Wang, Peng Kong, Xiaoyu Wang, Jie Wang, Xiaochao Zhang, Zhanfeng Zheng
Source: Catalysis Communications - Category: Chemistry Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ00959H, PaperKai Sheng, baoqian ji, Lei Feng, Yanmin Su, Marko Jagodic, Zvonko Jaglicic, Di Sun The reaction of one equivalent of 1,2-bis-(3,5-dimethylpyrazol-1-yl)-ethane-1,2-diol (H2bdped) with two equivalents of Ni(OAc)2 •4H2O afforded a hexanuclear nickel(II) cluster [Ni6(bdped)2(OAc)8(H2O)4]•6EtOH (SD/Ni6a). The single-crystal X-ray diffraction (SCXRD) structural analysis reveals the one-dimensional... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Proportion is far higher than those found in clinical trials of the cancer drugs; study finds differences by cancer type.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Diabetes & Endocrinology News Source Type: news
Purpose of review Chronic kidney disease (CKD) is a pervasive and growing health concern that has a significant impact on mortality and morbidity, putting stress on global healthcare systems. CKD affects ∼14% of general populations and ∼36% of high-risk populations and is projected to rise in the coming decade due to increasing rates of diabetes and hypertension. Recent findings Screen, triage, and treat programs aim to detect early stage disease with the intention of promoting medical and lifestyle interventions in line with a patient's level of risk that may slow disease progression and reduce morbidity and ...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: EPIDEMIOLOGY AND PREVENTION: Edited by Navdeep Tangri Source Type: research
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