Cancer survivor left 'infertile' as a teenager gives birth to a perfect baby girl

Kirstie Waldrum, 23, from Mountsorrel, Leicestershire, was diagnosed with leukaemia at age 13 and told the two-and-a-half years of intensive chemotherapy would leave her infertile.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

Related Links:

ConclusionThere is need to improve both the knowledge base and comfort level of pediatricians in counseling their patients during vaccine recommendations. Otolaryngologists have a critical role in providing education to physicians, trainees, and the general public in the effort to combat the epidemic of HPV-associated head and neck cancer.
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Conclusion: Our findings establish PLAC8 as a central mediator of cell growth in a subset of human PanNET, providing evidence for the existence of distinct molecular subtypes within this class of tumors.
Source: Neuroendocrinology - Category: Endocrinology Source Type: research
In conclusion, the spectrum of autoimmune reactions induced by immune-checkpoint inhibitors should be restricted in the near future to only these specific favorable autoimmune mechanisms. In this way, the unnecessary autoimmune reactions/autoaggressions could be avoided (a better quality of life), and treatment specificity and efficiency should increase (a higher response rate for melanoma therapy).
Source: Melanoma Research - Category: Cancer & Oncology Tags: REVIEW ARTICLES Source Type: research
Long noncoding RNA X-inactive specific transcript (XIST) was confirmed to participate in the development of many cancers. However, the function of XIST in malignant melanoma (MM) remained largely unknown. In the current study, we found that the XIST expression level was upregulated in MM tissues and cell lines. In addition, the growth rate of MM cells transfected with silencing XIST was significantly decreased compared with that with silencing normal control. XIST knockdown inhibited proliferation and migration in MM cells and increased the oxaliplatin sensitivity of oxaliplatin-resistant MM cells. Bioinformatics analysis ...
Source: Melanoma Research - Category: Cancer & Oncology Tags: ORIGINAL ARTICLES: Basic science Source Type: research
The recently developed therapeutic strategies have led to unprecedented improvements in the control of metastatic melanoma and in the survival of specific subgroups of patients. However, drug resistance, low response rates, and undesired side effects make these treatments not suitable or tolerable for all the patients, and chemotherapeutic treatments appear still indispensable, at least for subgroups of patients. New combinatory strategies are also under investigation as tailored treatments or salvage therapies, including combined treatments of immunotherapy with conventional chemotherapy. On this basis, and in considerati...
Source: Melanoma Research - Category: Cancer & Oncology Tags: ORIGINAL ARTICLES: Translational research Source Type: research
Patients diagnosed with metastatic melanoma have varied clinical courses, even in patients with similar disease characteristics. We examine the impact of initial stage of melanoma diagnosis, BRAF status of primary melanoma, and receiving adjuvant therapy on postmetastatic overall survival (pmOS). We studied melanoma patients presenting to Perlmutter Cancer Center at New York University and prospectively enrolled in New York University melanoma biospecimen database and followed up on protocol-driven schedule. Patients were stratified by stage at initial melanoma diagnosis as per AJCC 7th ed. guidelines. pmOS was determined ...
Source: Melanoma Research - Category: Cancer & Oncology Tags: ORIGINAL ARTICLES: Clinical research Source Type: research
AbstractChemotherapy-induced gonadal dysfunction resulting in transient or persistent infertility depends on the type of drugs and cumulative dose, and it is an important long-term complication, especially for adolescent and young adult (AYA) cancer patients. Due to its importance, a clinical practice guideline for fertility preservation in childhood and AYA cancer patients was published by the Japan Society of Clinical Oncology (JSCO) in 2017. Although the precise mechanisms remain unclear, several studies reported that the cancer itself, not the cancer treatment, adversely affected semen quality. It is reported that that...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Reported compliance with fertility preservation guidelines was greater than published rates. Higher compliance rates in female patients and in patients with cancers more common among young adults may reflect greater awareness of fertility-related concerns among these patients and their providers. PMID: 26957616 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
The UK papers today welcome news of a world first in fertility treatment. As The Guardian concisely summarises: "A young woman in Belgium has become the first to give birth to a healthy baby after having her fertility restored by a transplant of ovarian tissue that was removed and frozen when she was a child". The woman was born with sickle cell anaemia, a serious inherited blood disorder where the red blood cells, which carry oxygen around the body, develop abnormally. This can cause severe pain and organ damage. Due to the severity of her condition, a decision was taken to perform a stem cell transplant. This ...
Source: NHS News Feed - Category: Consumer Health News Tags: Medical practice Pregnancy/child QA articles Source Type: news
This study sought to establish rates of documentation of discussion of risk of infertility, fertility preservation (FP) options, and referrals to fertility specialists in AYA patients' medical records at four cancer centers. Methods: All centers reviewed randomized records within the top four AYA disease sites (breast, leukemia/lymphoma, sarcoma, and testicular). Eligible records included those of patients: diagnosed in 2011, with no prior receipt of gonadotoxic therapy; age 18 to 45 years; with no multiple primary cancers; and for whom record was not second opinion. Quality Oncology Practice Initiative methods were used ...
Source: Journal of Oncology Practice - Category: Cancer & Oncology Authors: Tags: Doctor-patient communication, Young adult, Clinical guidelines, Quality, Electronic health records, Clinical guidelines, Survivor Original Contributions Source Type: research
More News: Babies | Cancer | Cancer & Oncology | Cancer in Adolescents | Chemotherapy | Girls | Health | Infertility | Leukemia | Reproduction Medicine