Cancer survivor left 'infertile' as a teenager gives birth to a perfect baby girl

Kirstie Waldrum, 23, from Mountsorrel, Leicestershire, was diagnosed with leukaemia at age 13 and told the two-and-a-half years of intensive chemotherapy would leave her infertile.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): Alice H. Hsu, Michelle A. Lum, Kang-Sup Shim, Peter J. Frederick, Carl D. Morrison, Baojiang Chen, Subodh M. Lele, Yuri M. Sheinin, Takiko Daikoku, Sudhansu K. Dey, Gustavo Leone, Adrian R. Black, Jennifer D. BlackSummaryProtein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating evidence indicates that PKCs can be inhibitory in some cancers, with recent findings propelling a shift in focus to understanding tumor suppressive functions of these enzyme...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): James Monypenny, Hanna Milewicz, Fabian Flores-Borja, Gregory Weitsman, Anthony Cheung, Ruhe Chowdhury, Thomas Burgoyne, Appitha Arulappu, Katherine Lawler, Paul R. Barber, Jose M. Vicencio, Melanie Keppler, Wahyu Wulaningsih, Sean M. Davidson, Franca Fraternali, Natalie Woodman, Mark Turmaine, Cheryl Gillett, Dafne Franz, Sergio A. QuezadaSummaryThe immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA screen identified the endosomal sorting co...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): Mayura V. Wagle, Julia M. Marchingo, Jason Howitt, Seong-Seng Tan, Christopher C. Goodnow, Ian A. ParishSummaryEscape from peripheral tolerance checkpoints that control cytotoxic CD8+ T cells is important for cancer immunotherapy and autoimmunity, but pathways enforcing these checkpoints are mostly uncharted. We reveal that the HECT-type ubiquitin ligase activator, NDFIP1, enforces a cell-intrinsic CD8+ T cell checkpoint that desensitizes TCR signaling during in vivo exposure to high antigen levels. Ndfip1-deficient OT-I CD8+ T&...
Source: Cell Reports - Category: Cytology Source Type: research
MIDNIGHT fridge raiders are more at risk of developing breast or prostate cancer, research revealed last night.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: Comorbidities have a negative prognostic impact on overall survival in cancer patients, and should be assessed as risk factors for mortality when reporting outcomes. PMID: 30012908 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
Publication date: Available online 17 July 2018Source: The Annals of Thoracic SurgeryAuthor(s): Ju-Dong Li, Zi-Long Xiao, Xiao-Xiang Hou
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusions: Given the performance of the PBIC, it would be highly appropriate to use the device for therapeutic infusions in human clinical trials to assess its capability for large-volume infusions.Stereotact Funct Neurosurg
Source: Stereotactic and Functional Neurosurgery - Category: Neurosurgery Source Type: research
CONCLUSIONS: Reported compliance with fertility preservation guidelines was greater than published rates. Higher compliance rates in female patients and in patients with cancers more common among young adults may reflect greater awareness of fertility-related concerns among these patients and their providers. PMID: 26957616 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
The UK papers today welcome news of a world first in fertility treatment. As The Guardian concisely summarises: "A young woman in Belgium has become the first to give birth to a healthy baby after having her fertility restored by a transplant of ovarian tissue that was removed and frozen when she was a child". The woman was born with sickle cell anaemia, a serious inherited blood disorder where the red blood cells, which carry oxygen around the body, develop abnormally. This can cause severe pain and organ damage. Due to the severity of her condition, a decision was taken to perform a stem cell transplant. This ...
Source: NHS News Feed - Category: Consumer Health News Tags: Medical practice Pregnancy/child QA articles Source Type: news
This study sought to establish rates of documentation of discussion of risk of infertility, fertility preservation (FP) options, and referrals to fertility specialists in AYA patients' medical records at four cancer centers. Methods: All centers reviewed randomized records within the top four AYA disease sites (breast, leukemia/lymphoma, sarcoma, and testicular). Eligible records included those of patients: diagnosed in 2011, with no prior receipt of gonadotoxic therapy; age 18 to 45 years; with no multiple primary cancers; and for whom record was not second opinion. Quality Oncology Practice Initiative methods were used ...
Source: Journal of Oncology Practice - Category: Cancer & Oncology Authors: Tags: Doctor-patient communication, Young adult, Clinical guidelines, Quality, Electronic health records, Clinical guidelines, Survivor Original Contributions Source Type: research
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