The IL4-VNTR P1 allele, IL4-VNTR P2P2 genotype and IL4-VNTR_IL6-174CG P2P1-GG genotype are susceptable with a increased risk in Brucelosis.

This study aimed to investigate the association of IL-4, IL-6 and Macrophage migration inhibitory factor (MIF) polymorphisms and the susceptibility to Brucellosis. Consecutive adult patients with no known treatment against Brucellosis (n=120, Group I, ) who had no any other autoimmune and/or chronic disorders were included for the study. Age and sex matched controls who had no other autoimmune and/or chronic disorders were (n=120, healthy volunteers, Group II) selected as well. IL4_P2P2 genotype, IL4_P1 allele and IL4_VNTR-IL6_174CG compound genotype were frequent in the patient group compared to control subject and there were significant differences between the patients and the controls for the IL4_ P2P2 genotype (77.5% versus 87.5%; p<0.001; Cl: 0.36 (0.21-0.62)) and IL4_P1 allele (12.1% versus 6.7%; p<0.030; Cl: 0.92 (1.02-3.64)). The IL4-VNTR_IL6-174CG compound genotype was also present at significantly higher frequency in the patient compared to control subjects (11.7% versus 4.2%; p<0.027, Cl:3.04, (1.06-8.68)). No statistically significant differences in the frequencies of the IL-6_174, MIF-173 or IL-4_P1P1 and IL4_P2P1 genotypes were observed between patients and control subjects. The IL4_VNTR P1 allele and P2P2 genotypes and IL4_VNTR-IL6_174CG P2P1-GG genotypes are common in southern part of Turkey and carriers of those polymorphisms are susceptible to Brucelosis. PMID: 27169944 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research