Abstract IA23: Hippo/YAP signaling in stem cells and cancer

The long-term goals of the Camargo laboratory are to provide basic insight into conserved mechanisms underlying size and growth control. We are particularly interested in the pathways that somatic stem and progenitors cells utilize to sense and respond to growth inputs in vivo. We utilize the mouse as a genetic model to study pathway function and to dissect the mechanisms by which growth control is coordinated. We also employ three-dimensional primary culture, biochemistry, and high-throughpout genetic interrogation in vitro to identify novel growth-control genes and to provide basic molecular mechanisms underlying our in vivo observations. Additionally, my lab is pursuing the development of novel technologies for lineage tracing of mammalian stem cells. We are particularly interested in studying the function of the Hippo/YAP signaling pathway and its effects on tissue size, homeostasis and cancer. We have demonstrated that Hippo signaling can be a very potent regulator of organ size in mice and have provided a conceptual link between organ size regulation and stem cell activity through Hippo signals. Studies exploring the molecular basis of YAP-driven phenotypes will be discussed.Citation Format: Fernando Camargo. Hippo/YAP signaling in stem cells and cancer. [abstract]. In: Proceedings of the AACR Special Conference: Developmental Biology and Cancer; Nov 30-Dec 3, 2015; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(4_Suppl):Abstract nr IA23.
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: Signaling Pathways: Hippo/TOR: Oral Presentations - Invited Abstracts Source Type: research