ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese

Publication date: Available online 12 May 2016 Source:Meta Gene Author(s): Chengjun Sun, Haiyan Wei, Xiuli Chen, Zhuhui Zhao, Hongwei Du, Wenhui Song, Yu Yang, Miaoying Zhang, Wei Lu, Zhou Pei, Li Xi, Jian Yan, Dijing Zhi, Ruoqian Cheng, Feihong Luo Type 1 diabetes (T1D) is an autoimmune disease that has strong contribution of genetic factors to its etiology. We aimed to assess the genetic association between non-HLA genes and T1D in a Chinese case-control cohort recruited from multiple centers consisting of 364 patients with T1D and 719 unrelated healthy children. We genotyped 55 single nucleotide polymorphisms (SNP) markers located in 16 non-HLA genes (VTCN1, PTPN22, CTLA4, SUMO4, CD274, IL2RA, INS, DHCR7, ERBB3, VDR, CYP27B1, CD69, CD276, PTPN2, UBASH3A, and IL2RB) using SNaPshot multiple single-base extension methods. After multivariate analysis and correction for multiple comparisons, we identified the SNP rs2292239 in ERBB3 gene were significantly associated with T1D. The frequency of the major G allele was significantly decreased in patients with T1D (68.8% in T1D vs 77.3% in controls, OR 0.65, 95% CI 0.53–0.79, P =0.02), and the minor allele T was associated with an increased risk of T1D (OR 1.55, 95% CI 1.26–1.90, P =0.02). Our haplotype analysis confirmed that rs2292239 was the primary T1D association locus in our current investigation. These results indicated that the ERBB3-rs2292239 was the primary T1D association locus among ...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research