Bioengineered Blood Vessel Appears Safe for Dialysis Patients

Contact: Sarah Avery Phone: 919-660-1306 Email: EMBARGOED FOR RELEASE until 6:30 p.m. (ET) on Thursday, May 12, 2016. DURHAM, N.C. – Man-made blood vessels developed by researchers at Duke University, Yale University and the tissue engineering company Humacyte appear to be both safe and more durable than commonly used synthetic versions in patients undergoing kidney dialysis, the researchers report. The findings, published May 12 in The Lancet, resulted from a phase 2 study among 60 patients with kidney failure who required dialysis, which often requires a synthetic graft when the patient’s own blood vessel degrades from frequent needle sticks. Such grafts, however, are prone to infection, clotting, and other complications. And alternative bioengineered grafts derived from the patient, a donor, or animal tissue have been shown to perform no better than synthetics.  The Duke and Yale research team -- along with surgeons in Poland and the United States and scientists at Humacyte, which is developing the bioengineered vessel -- tested a human acellular vessel, or HAV, that is manufactured to be  available to patients on demand, rather than made-to-order using an individual’s own cells.   “The bioengineered blood vessel represents a critical step in tissue engineering,” said Jeffrey Lawson, M.D., Ph.D., professor of surgery and pathology at Duke and chief medical officer of Humacyte. &ld...
Source: Duke Health Features - Category: Pediatrics Tags: Duke Medicine Source Type: news

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Publication date: December 2019Source: European Urology Supplements, Volume 18, Issue 12Author(s): A. Tataradze, V. Shoshiashvili, L. Beglarishvili, A. Chkhotua
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: December 2019Source: European Urology Supplements, Volume 18, Issue 12Author(s): A. Tataradze, V. Shoshiashvili, L. Beglarishvili, A. Chkhotua
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
CONCLUSION: Outflow reconstruction through the elbow bypass by cubital vein transposition is a valuable resource to rescue radiocephalic arteriovenous fistula complicated by outflow obstruction, avoiding the use of an interim central vein catheter. Endovascular treatment is vital to maintain functional patency in the mid- and long term. PMID: 31774035 [PubMed - as supplied by publisher]
Source: The Journal of Vascular Access - Category: Surgery Tags: J Vasc Access Source Type: research
A 42-YEAR-OLD woman on hemodialysis with a history of end-stage renal disease, left ventricular ejection fraction of 45%, mean pulmonary artery pressure of 45 mmHg, and severe tricuspid regurgitation had several recent hospitalizations for worsening dyspnea on exertion and peripheral edema. She denied intravenous drug abuse, carcinoid symptoms, trans-tricuspid valve instrumentation, or any known congenital conditions. Preoperative transthoracic echocardiography demonstrated incomplete tricuspid leaflet coaptation despite normal leaflet structure and mobility.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Diagnostic Dilemma Source Type: research
We report a case of a 59-year-old female patient with vegetative native mitral valve endocarditis caused by Stenotrophomonas maltophilia (SM). She had hemodialysis-dependent chronic renal failure, but no immunosuppressive disease. Echocardiography showed mobile vegetation on her native mitral valve. Right femoral artery embolectomy and mitral valve replacement were performed simultaneously. She awakened from anesthesia, but she passed away due to septic shock complications. To the best of our knowledge, this was the first case in whom native mitral valve endocarditis caused by SM was observed (despite of absence of any imm...
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
Suspected seizure-survival of a lethal dose of the rodenticide alpha-chloralose. Anaesthesist. 2019 Nov 07;: Authors: Bergrath S, Castillo-Vargas JS, Koc NJ, Haake H, Graeven U Abstract A 58-year-old female was admitted due to a suspected seizure. A blue colored pharyngeal fluid was visualized during intubation, which is indicative of poisoning. Clinical research revealed an ingestion of 2.4 g of alpha-chloralose, a rodenticide with a lethal dose of 1 g. Immediate detoxification by gastroscopy, gastric lavage and hemodialysis led to full recovery. Substance detection ...
Source: Der Anaesthesist - Category: Anesthesiology Authors: Tags: Anaesthesist Source Type: research
Publication date: November 2019Source: The Journal of Foot and Ankle Surgery, Volume 58, Issue 6Author(s): Peter Kaiser, Thomas Vincent Häller, Ilker Uçkay, Dominik Kaiser, Martin Berli, Thomas Böni, Felix WaibelAbstractTotal transmetatarsal amputation (TMA) can be an option for foot salvage in gangrene, sepsis, or infected necrosis. However, the literature concerning predictive outcome factors and bacterial sampling is scarce. To identify potential associations between revision surgery and underlying bacteria or other preoperative selection criteria, we reviewed all patients with TMA who were treated at o...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Primary arteriovenous fistula (AVF) remains the best vascular access for hemodialysis since it has the best long-term primary patency rate, requires less interventions/maintenance, and has the lowest incidence of morbidity and mortality. For this reason, the National Kidney Foundation began the “Fistula First Breakthrough Initiative”, which seeks to increase the amount of successful AVFs placed. Multiple factors play a role in primary AVFs creation; Vein diameter/quality, artery diameter/quality, central venous disease, hypercoagulable states and fistula location.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Source Type: research
ConclusionIn this large observational study using a national clinical database, obese patients undergoing PD for head of pancreas cancer had increased risk of postoperative complications and mortality in comparison to controls.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Conclusions: Female gender, increasing age, American Society of Anesthesiology classification, operative time, or a history of diabetes, chronic obstructive pulmonary disease, congestive heart failure, or a bleeding disorder are risk factors for prolonged hospitalization following total shoulder arthroplasty. Level of Evidence: Level III.
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
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