Skin disease of penis and male genitalia is linked to atopy and circumcision: caseload in a male genital dermatology clinic

ConclusionsThe diagnoses made were described, including their associations with non‐circumcision and atopy. Several of these observations have not been recognised before in the literature. We discuss lessons learned in the management of male genital disease and its psychosocial impact.
Source: Australasian Journal of Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research

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Authors: Mendes JT, Balogh EA, Strowd LC, Feldman SR Abstract Introduction: Moderate-to-severe AD burdens a large proportion of AD patients and may represent an inadequacy of treatment options available for resistant disease.Areas covered: This review provides an overview of the therapies for moderate-to-severe AD in late-stage development and in the clinic, and focuses on baricitinib as an emerging therapeutic option. Baricitinib is an orally available selective JAK1/JAK2 inhibitor that is approved for use in the treatment of moderate-to-severe rheumatoid arthritis (RA). Baricitinib decreases AD lesions, disease s...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: Available online 27 March 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): M. Munera-Campos, J.M. Carrascosa
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
We examined the pattern of toll-like receptor 2 (TLR2), TLR4, TLR7, interleukin- (IL-) 10, interferon gamma (IFN-γ), and (program death ligand) PD-L1 gene expression in LST-positive reactions and paired normal-looking skin of nine infected Ibizan hound dogs. Healthy skin from ten seronegative dogs from a nonendemic area was analysed as a negative control. Immune gene expressions were examined by quantitative PCR (qPCR) analysis. LST-positive reactions presented significant upregulation of TLR2, TLR4, IL-10, IFN-γ, and PD-L1 and downregulation of TLR7 when compared with healthy skin of seronegative control dogs ...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Itch, initiated by the activation of sensory neurons, is frequently associated with dermatological diseases. MrgprA3+ sensory neurons have been identified as one of the major itch-sensing neuronal populations. Mounting evidence has demonstrated that peripheral pathological conditions induce physiological regulations of sensory neurons, which is critical for the maintenance of chronic itch sensation. However, the underlying molecular mechanisms are not clear. Here we performed RNA sequencing of genetically labeled MrgprA3+ neurons under both na ïve and allergic contact dermatitis conditions.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Shih-Jen Liu Dendritic cells (DCs) are antigen-presenting cells involved in T cell activation and differentiation to regulate immune responses. Lipoimmunogens can be developed as pharmaceutical lipoproteins for cancer immunotherapy to target DCs via toll-like receptor 2 (TLR2) signaling. Previously, we constructed a lipoimmunogen, a lipidated human papillomavirus (HPV) E7 inactive mutant (rlipoE7m), to inhibit the growth of HPV16 E7-expressing tumor cells in a murine model. Moreover, this antitumor effect could be enhanced by a combinatory treatment with CpG oligodeoxynucleotides (ODN). To improve safety, we developed...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Park The critical roles of keratinocytes and resident mast cells in skin allergy and inflammation have been highlighted in many studies. Cyclic adenosine monophosphate (cAMP), the intracellular second messenger, has also recently emerged as a target molecule in the immune reaction underlying inflammatory skin conditions. Here, we investigated whether undecane, a naturally occurring plant compound, has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes and we further explored the potential involvement of the cAMP as a molecular target for un...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
We recognize that there are certain questions for which the answer is manifestly obvious and therefore do not need research to answer. Most famously, this was shown in a meta-analysis of parachute use when jumping out of airplanes.(1) That said, we must push back against a commentary which essentially argues that this treatment works because people say it works. If we had continued to follow this principle, we would still be injecting organic mercury as a diuretic (effective in dehydrating British medical students (2)), sprinkling asbestos on the heart to ward off pericardial effusions (3), and countless other since-debunked therapies.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
Condition:   Atopic Dermatitis Intervention:   Sponsors:   MYOR Ltd.;   Meir Medical Center;   The Baruch Padeh Medical Center, Poriya Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Coronavirus Infection Intervention:   Diagnostic Test: Nasopharyngeal swab Sponsors:   Universita di Verona;   Azienda Ospedaliera Universitaria Integrata Verona Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: The diagnoses made were described, including their associations with non-circumcision and atopy. Several of these observations have not been recognised before in the literature. We discuss lessons learned in the management of male genital disease and its psychosocial impact. PMID: 27170096 [PubMed - as supplied by publisher]
Source: The Australasian Journal of Dermatology - Category: Dermatology Authors: Tags: Australas J Dermatol Source Type: research
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