Integrating Mutation Variant Allele Frequency into Clinical Practice in Myeloid Malignancies

Publication date: Available online 11 May 2016 Source:Hematology/Oncology and Stem Cell Therapy Author(s): David A. Sallman, Eric Padron Hematologic myeloid neoplasms represent a heterogeneous group of disorders with defined clinical and pathologic characteristics. However, intensive investigation into the genetic abnormalities of these diseases has not only significantly advanced our understanding, but also revolutionized our diagnostic and prognostic capabilities. Moreover, more recent discovery on the impact of clonal burden has highlighted the critical and dynamic role of clonal evolution over time, which is integrally linked to a patient’s clinical trajectory. This review will highlight the evidence supporting the incorporation of allelic burden of somatic mutations into clinical practice for the diagnosis and prognosis of myeloid neoplasms.
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research