Aberrant BLM cytoplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer
Conclusions
Taken together, the findings of this study provide the first evidence that cancer-linked DNA hypomethylation and cytosolic BLM mislocalization might reflect compromised levels of DNA-repair activity and enhanced hypersensitivity to DNA-damaging agents in CRC patients.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
More News: Ataxia | Cancer | Cancer & Oncology | Colorectal Cancer | Gastroenterology | Gastroschisis Repair | Genetics | Study