Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria.

CONCLUSION: PH1 Ur-PROs reflected overt inflammation, chemotaxis, oxidative stress, growth factors (including EGF), and pro-angiogenic and calcification regulation/inhibition compared to the C and IHC cohorts. Many of the up- and downregulated PH1-PROs found in this study are also found in CKD, acute kidney injury, stone formers, and/or stone matrices. Further data analyses may provide evidence for PH1 unique PROs or demonstrate a poorer clinical outcome.
PMID: 27161247 [PubMed - as supplied by publisher]

Source: American Journal of Nephrology - May 2, 2016 Category: Urology & Nephrology Authors: Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB Tags: Am J Nephrol Source Type: research