Was Beethoven’s deafness caused by lead toxicity?

3 out of 5 stars Lead and the Deafness of Ludwig Van Beethoven. Stevens MH et al. Laryngoscope 2013 Nov;123:2854-2858. Abstract Beethoven was 27 when he first experienced tinnitus and high-frequency hearing impairment. These symptoms progressed slowly until the famous incident in 1824 when the composer, attending the first performance of his Ninth Symphony, he was not able to hear the thunderous applause that followed. The authors of this interesting article consider some previously theories proposed to explain Beethoven’s deafness, and find reasons to rule them out: Autoimmune hearing loss – While this progresses rapidly over weeks or months, Beethoven’s symptoms worsened slowly over years. Mercury toxicity from treatment for syphilis - There is no evidence that Beethoven had syphilis, and no mercury was detected in samples of his bone or hair. Otosclerosis – Arguing against this is the fact that findings consistent within this diagnosis were not documented at autopsy. The authors argue, rather, that Beethoven’s deafness was the result of chronic lead toxicity. In fact, analysis of a sample of Beethoven’s hair at the Argonne National Laboratory did demonstrate the presence of lead. Exposure might have resulted from the composer’s well-known fondness for wine, which was often contaminated with the heavy metal. This theory had been rejected in the past, because there is no evidence that Beethoven had other neurological mani...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical beethoven deafness hearing loss lead ototoxicity plumbism Source Type: news

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Abstract Objective: The present study assessed epidemiological and obstetrical data from pregnant women with syphilis at the Hospital de Cl ínicas of the Universidade Federal do Triângulo Mineiro (UFTM, in the Portuguese acronym), describing this disease during pregnancy and its vertical transmission for future healthcare actions. Methods: Records from pregnant women who had been admitted to the Obstetrics Department of the Hospital de Clínicas of the UFTM and were diagnosed with syphilis between 2007 and 2016 were reviewed. A standardized form was used to collect epidemiological, obstetric data and out...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Abstract Background: Studies on toad poison are relevant since they are considered a good source of toxins that act on different biological systems. Among the molecules found in the toad poison, it can be highlighted the cardiotonic heterosides, which have a known mechanism that inhibit Na+/K+-ATPase enzyme. However, these poisons have many other molecules that may have important biological actions. Therefore, this work evaluated the action of the low molecular weight components from Rhinella schneideri toad poison on Na+/K+-ATPase and their anticonvulsive and / or neurotoxic effects, in order to detect molecules with acti...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - Category: Tropical Medicine Source Type: research
If You’re Depressed, Why Bother Getting Up&Ready for the Day?I was recently asked if I had a blog post about why I cared so much about my dress, hair, and appearance despite my depression. What drives me to bother cleaning up when laying in bed while reading news in my PJs is easier to do? Why bother shaving? Why bother showering? Why bother getting up at all?I couldn’t find a specific blog where I addressed this issue, but the pat answer is that my vanity is a super power. Vanity overpowers the darkest, deepest depressions to make sure at least my hair is presentable. Doesn’t that sound superficial? ...
Source: The Splintered Mind by Douglas Cootey - Category: Psychiatry Tags: Depression Family Goodreads Suicide Source Type: blogs
(Natural News) Today, the internet, often thought of as our world’s “final frontier” for free thinkers and the flow and exchange of ideas and information, is seriously ill. It has been systemically infected by ideological viruses, memes of information intent on poisoning freedom of expression that we take for granted every time we use Google...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Carbon monoxide poisoning. Carbon monoxide poisoning is a frequent and serious intoxication with an important pre-hospital mortality. The diagnosis is made by the association of a context and compatible neurological and cardiac clinical signs. This diagnos...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
BACKGROUND: Acute poisoning in geriatric age group is a clinical challenge due to multiple comorbidities and complications in this age group. There are very few studies done in the past, which have addressed this issue. MATERIALS AND METHODS: This ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Publication date: 16 April 2019Source: Cell Reports, Volume 27, Issue 3Author(s): Valentina Sica, Jose Manuel Bravo-San Pedro, Valentina Izzo, Jonathan Pol, Sandra Pierredon, David Enot, Sylvère Durand, Noélie Bossut, Alexis Chery, Sylvie Souquere, Gerard Pierron, Evangelia Vartholomaiou, Naoufal Zamzami, Thierry Soussi, Allan Sauvat, Laura Mondragón, Oliver Kepp, Lorenzo Galluzzi, Jean-Claude Martinou, Holger Hess-StumppSummaryInhibition of oxidative phosphorylation (OXPHOS) by 1-cyclopropyl-4-(4-[(5-methyl-3-(3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl]pyridin-2-y...
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Conclusion: The pitch mismatch was smaller for the perimodiolar electrode array than for the lateral wall electrode array.Audiol Neurotol 2019;24:38 –48
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Conclusion: Our findings indicate that the genetic test based on WES can be useful in diagnosing SYM1 patients, with particular advantages in preventing the fetus from contacting harmful X-ray through the traditional radiography. The novel pathogenic mutation identified would further expand our understanding of the mutation spectrum of NOG in association with SYM1 disease and provide a guidance on how to determine whether the fetus is affected by SYM1 through the prenatal diagnosis. Introduction Proximal symphalangism (MIM#185800, SYM1) is a rare autosomal dominant bone disorder with principal features of variable ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion and Perspectives Collectively, previous studies showed that numerous types of TCMs protect against AKI via different mechanisms of action, including inhibiting inflammation, cell apoptosis, necroptosis, ferroptosis, and restraining oxidative stress etc. These data support the potential application of these TCMs as novel therapeutic agents in treating patients with AKI. Although some TCMs have entered preclinical trials, it is essential to initiate pre-clinical pharmacologic and toxicologic trials and clinical trials to evaluate the efficacy and safety of TCMs usage. Moreover, considering that some TCMs are dele...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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