Was Beethoven’s deafness caused by lead toxicity?

3 out of 5 stars Lead and the Deafness of Ludwig Van Beethoven. Stevens MH et al. Laryngoscope 2013 Nov;123:2854-2858. Abstract Beethoven was 27 when he first experienced tinnitus and high-frequency hearing impairment. These symptoms progressed slowly until the famous incident in 1824 when the composer, attending the first performance of his Ninth Symphony, he was not able to hear the thunderous applause that followed. The authors of this interesting article consider some previously theories proposed to explain Beethoven’s deafness, and find reasons to rule them out: Autoimmune hearing loss – While this progresses rapidly over weeks or months, Beethoven’s symptoms worsened slowly over years. Mercury toxicity from treatment for syphilis - There is no evidence that Beethoven had syphilis, and no mercury was detected in samples of his bone or hair. Otosclerosis – Arguing against this is the fact that findings consistent within this diagnosis were not documented at autopsy. The authors argue, rather, that Beethoven’s deafness was the result of chronic lead toxicity. In fact, analysis of a sample of Beethoven’s hair at the Argonne National Laboratory did demonstrate the presence of lead. Exposure might have resulted from the composer’s well-known fondness for wine, which was often contaminated with the heavy metal. This theory had been rejected in the past, because there is no evidence that Beethoven had other neurological mani...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical beethoven deafness hearing loss lead ototoxicity plumbism Source Type: news

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This study used an operant conditioning animal model to examine the interaction between tinnitus and auditory vigilant attention as well as auditory selective attention. Tinnitus was induced in 90-day-old rats by a unilateral exposure to band-limited noise (120 dB, SPL). Tinnitus testing began 90 days following exposure; afterward animals were divided into 3 groups: Unexposed controls without tinnitus, Exposed without tinnitus, and Exposed with tinnitus. Tinnitus was evident in the vicinity of 20 kHz. Vigilant attention was quantified by the behavioral (operant) response to unpredictable sound transitions signaling changes...
Source: Neuroscience - Category: Neuroscience Source Type: research
Conclusions: Based on these preliminary data, patients with clinically evident symptoms of dementia, especially middle-aged males, should undergo blood tests for syphilis. All patients with positive serology results should undergo CSF examinations to diagnose GP dementia before further pharmaceutical and behavioral interventions.Eur Neurol 2018;80:82 –86
Source: European Neurology - Category: Neurology Source Type: research
Publication date: Available online 18 October 2018Source: NeuronAuthor(s): Jane Y. Chen, Carlos A. Campos, Brooke C. Jarvie, Richard D. PalmiterSummaryFood aversions develop when the taste of a novel food is associated with sickness, which often occurs after food poisoning or chemotherapy treatment. We identified calcitonin-gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) as sufficient and necessary for establishing a conditioned taste aversion (CTA). Photoactivating projections from CGRPPBN neurons to either the central nucleus of the amygdala or the bed nucleus of the stria terminalis can also induce...
Source: Neuron - Category: Neuroscience Source Type: research
See something of interest? Please share our postings with colleagues in your institutions! Spotlight The MAReport: read the Summer/Fall 2018 issue of the MAReport newsletter! This quarter, Health Professions Coordinator Erin Seger wrote about her experiences at the 17th annual Philadelphia Trans Wellness Conference, and LGBT health information needs in her article, “LGBT Health Information Resources.” Member Highlights: Stony Brook University, Southampton, NY – learn about how the Applied Health Informatics Program at Stony Brook used NNLM MAR funding to conduct a Wellness Fair for seniors, and later...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Weekly Postings Source Type: news
Condition:   Hearing Loss Intervention:   Procedure: FNIRS Observational Sponsor:   University of Michigan Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Jones ML, Morris JT, Mueller JL, Lippincott B, Sweatman WM Abstract Accessibility of telecommunication technologies by people who are deaf or hard of hearing has been a critical issue since the invention of the telephone. As both telephone and hearing-aid technologies have evolved, finding compatible solutions has been an ongoing challenge. This paper uses the findings of a longitudinal study to examine the impact of Federal hearing-aid compatibility (HAC) regulations in resolving this problem. The study ran concurrently with the phase-in of Federal Communications Commission regulations requiring that mobi...
Source: Assistive Technology - Category: Rehabilitation Tags: Assist Technol Source Type: research
This study applied Best–Worst Scaling (BWS) to understand residents’ anxieties about potential incidents caused by climate change in Amami islands, Japan. Through an interview with stakeholders, we selected five potential incidents for our BWS attributes: damage caused by typhoon and heavy rain (typhoon), damage caused by flood and a landslide (flood), damage from a drought (drought), damage from ciguatera fish poisoning (ciguatera), and incident caused by jellyfish (jellyfish). Changes in frequencies of the abovementioned incidents have already been observ ed in Japan. In 2016, we conducted a questionnaire sur...
Source: Sustainability Science - Category: Science Source Type: research
Conclusions: The GWQR models enabled us to explore the full distribution of children’s lead poisoning and identify “high risk” locations or areas in the neighborhood of the inner city of Syracuse, which would provide useful information to assist the government agencies to make better decisions on where and what the lead hazard treatment should focus on.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Lee Sign language is intentionally designed to allow deaf and dumb communities to convey messages and to connect with society. Unfortunately, learning and practicing sign language is not common among society; hence, this study developed a sign language recognition prototype using the Leap Motion Controller (LMC). Many existing studies have proposed methods for incomplete sign language recognition, whereas this study aimed for full American Sign Language (ASL) recognition, which consists of 26 letters and 10 digits. Most of the ASL letters are static (no movement), but certain ASL letters are dynamic (they require certa...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
CONCLUSIONS: We showed an increased malignant transformation rate in recurrent leukoplakia cases among heavy smokers and male patients. In addition, severe dysplasia at initial diagnosis was a risk factor for SCC development. Close follow-up of patients with recurrent leukoplakia is warranted. PMID: 30324779 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
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