Big Pharma Just Bet $10 Billion On A Cancer Drug Startup. Here's Why.

Question: What do WhatsApp and a little-known (until recently) cancer research startup named Stemcentrx have in common? Answer: They're the top two largest private venture-backed acquisitions in history, after pharmaceutical giant AbbVie acquired the drug company earlier this month in a deal that values it at as high as $10 billion. (Facebook acquired WhatsApp in 2014 for $19 billion.) Not bad for a company that has yet to bring a product to market. What Stemcentrx (pronounced "stem-centrix") does have, however, is a unique -- and somewhat controversial -- approach to treating several forms of cancer. While most of today's treatments view cancer as a result of unchecked cell growth, wherein any cell is capable of becoming cancerous, Stemcentrx believes that cancer primarily sprouts from only one cell type: cancer stem cells. Cells in our bodies are constantly dying and being birthed anew. This process relies on stem cells, which are basically just cells that can grow into many other different types of cells. Over time, Stemcentrx's Chief Science Officer Dr. Scott Dylla told HuffPost, those stem cells -- like any other cell -- can accumulate genetic mutations. Given enough mutations, says Dylla, they may begin "to act abnormally and no longer play nice with their neighbors." In other words, they become cancerous. The stem cell theory of cancer posits that rogue stem cells are responsible for growing and perpetuating cancer, and that, unless the stem ce...
Source: Science - The Huffington Post - Category: Science Source Type: news

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(MedPage Today) -- Intervention doubled peak oxygen consumption
Source: MedPage Today Hematology/Oncology - Category: Hematology Source Type: news
Authors: Jing LW, Zhang C, Jin F, Wang AP Abstract BACKGROUND There is a great need for a quality of sexual life questionnaire (QVS) in breast cancer survivors (BCSs) based on the Chinese social culture since the imported tools lack localization verification. To develop a QVS in BCSs and determine its validity and reliability. MATERIAL AND METHODS In the qualitative study, a total of 21 BCSs were interviewed by purposive sampling and snowball sampling; and in the quantitative study, a total of 249 BCSs, who were admitted and received outpatient follow-up, were investigated. Regarding construct validity, factor anal...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS All these findings demonstrate that Bevacizumab treatment ameliorated cartilage degradation in rats subjected to chronic sports arthritic injury. Our results provide evidence supporting use of targeted therapy for VEGF in the clinical treatment of chronic sports arthritic injury. PMID: 29904041 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Abstract The utilization of human pluripotent stem cells holds great promise in elucidating principles of developmental biology and applications in personalized and regenerative medicine. Breakthroughs from the last decade have allowed the scientific community to better understand and successfully manipulate human pluripotent stem cells using distinct differentiation strategies into a variety of target tissues. This manipulation relies solely on our understanding of developmental processes occurring in model organisms. The in vitro translation of our developmental knowledge upon stem cells provides a new means to ...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
Authors: Le Bot A, Jégo P, Donal E, Flécher E, Revest M, Tattevin P Abstract Non-infective endocarditis, also referred to as non-bacterial thrombotic endocarditis, represent a wide range of rare pathologies, often severe. This review gathered the data available in the literature, to decipher the major information collected on the pathophysiology, the diagnosis and the treatment of these heterogeneous diseases, often misdiagnosed. Characteristics of non-infective endocarditis are similar to infective endocarditis in terms of valvular lesions (mostly left-sided, with regurgitations and vegetations), and...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
In this study, we generated baseline information fundamental to developing a successful control program by estimating the stray cat population size, density, and spatial distribution. Furthermore, we quantified the number of neutered cats and developed a spatial database to include information about the external physical condition of each individual. We estimated a population of 178 (±21) cats, with a density of 3.6 cats/ha. Overall, we observed 209 cats, from which 149 (71%) were identified as new and 60 (29%) were recaptured. We found stray cats had a significant non-random and clustered spatial distribution (z-sc...
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
Authors: Turhan E, Yasli G Abstract OBJECTIVE: The present study was performed to detect cancer risk of the midwifes and nurses playing central role in raising awareness in the society using Gail's model. MATERIALS AND METHODS: Sample of the present cross sectional study consists of 750 volunteer midwifes and nurses in 2016. Breast cancer risk was calculated using the Gail Risk Assessment Tool. Perceived and calculated risk levels were compared. Descriptive statistics and Chi-Square analysis, t-test, Multivariate Linear Regression Analysis, the Logistic Regression Analysis were conducted. RESULTS: A mean of...
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
CONCLUSIONS AND RELEVANCE: Red eyes, conjunctivitis, and anterior uveitis occur frequently in patients with Chikungunya fever. Systemic diseases, such as diabetes, hypertension, and cancer, may increase the risk of such ocular manifestations. Routine ophthalmic evaluation is warranted in patients with these medical conditions. The relevance of this study lies in the fact that this disease remains an important public health issue, since such ocular sequelae as may be present can range from mild to severe, either as an acute or a delayed manifestation. PMID: 29905918 [PubMed - in process]
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
PROSTATE cancer happens when problems in an area of the male reproductive system cause cells to start dividing uncontrollably. You ’re more at risk of prostate cancer if you’re older, overweight or have a family history of the cancer. However, eating this red food can help you prevent the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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