Big Pharma Just Bet $10 Billion On A Cancer Drug Startup. Here's Why.
Question: What do WhatsApp and a little-known (until recently) cancer research startup named Stemcentrx have in common? Answer: They're the top two largest private venture-backed acquisitions in history, after pharmaceutical giant AbbVie acquired the drug company earlier this month in a deal that values it at as high as $10 billion. (Facebook acquired WhatsApp in 2014 for $19 billion.) Not bad for a company that has yet to bring a product to market. What Stemcentrx (pronounced "stem-centrix") does have, however, is a unique -- and somewhat controversial -- approach to treating several forms of cancer. While most of today's treatments view cancer as a result of unchecked cell growth, wherein any cell is capable of becoming cancerous, Stemcentrx believes that cancer primarily sprouts from only one cell type: cancer stem cells. Cells in our bodies are constantly dying and being birthed anew. This process relies on stem cells, which are basically just cells that can grow into many other different types of cells. Over time, Stemcentrx's Chief Science Officer Dr. Scott Dylla told HuffPost, those stem cells -- like any other cell -- can accumulate genetic mutations. Given enough mutations, says Dylla, they may begin "to act abnormally and no longer play nice with their neighbors." In other words, they become cancerous. The stem cell theory of cancer posits that rogue stem cells are responsible for growing and perpetuating cancer, and that, unless the stem ce...
ConclusionsFoot orthoses can relieve pain and disability and enhance patients, but no significant differences were found between control and intervention groups.
ConclusionA DTF-specific HRQL tool and consensus regarding the preferred measurement tool among DTF patients is lacking. Our study indicates that HRQL of DTF patients was negatively affected in several domains. A DTF-specific HRQL measure could improve our understanding of short- and long-term effects and, ideally, can be used in both clinic and for research purposes.
Authors: Vajaitu C, Draghici CC, Solomon I, Lisievici CV, Popa AV, Lupu M, Caruntu C, Constantin MM, Voiculescu VM Abstract An important function of the immune system is its ability to differentiate between healthy cells in the organism and "foreign" cells, allowing the latest to be attacked and the first ones to be conserved. The most important molecules in this process are considered to be checkpoint inhibitors. This review is focused on the association between cancer and inflammation, underlying the mechanisms of action of monoclonal antibodies that are targeting checkpoint inhibitors: ipilimumab again...
In this study, we isolated specific anti-ICOSL new antigen receptor domains from a synthetic phage display library and demonstrated their ability to block the ICOS/ICOSL interaction and inhibit T cell proliferation. Anti-mouse ICOSL domains, considered here as surrogates for the use of anti-human ICOSL domains in patient therapy, were tested for efficacy in a collagen-induced mouse model of rheumatoid arthritis where they significantly decreased the inflammation of joints and delayed and reduced overall disease progression and severity. PMID: 30417018 [PubMed - in process]
CONCLUSIONS: Acknowledging the limitations of a retrospective analysis, our study confirms previous real-world evidence suggesting that continuing advances in the treatment of mRCC has led to improved outcomes in everyday practice worldwide. Pharmacoeconomic analyses are important for cost effective utilization of emerging novel therapies. PMID: 30417707 [PubMed - as supplied by publisher]
Authors: Zhou J, Zheng S, Liu T, Liu Q, Chen Y, Ma R, Tan D, Lu X Abstract Although M2 tumour-associated macrophages (M2 TAMs) have been shown to be associated with the progression and metastasis of breast cancer, their role in oesophageal squamous cell carcinoma (ESCC) remains less well understood. Therefore, to understand the clinicopathological significance of infiltrated M2 TAMs in ESCC, statistical analysis was performed after immunohistochemical evaluation of CD163 expression, a well-accepted surface marker of M2 TAMs in ESCC. To gain insight into the effect of M2 TAMs, ESCC cell lines Eca109 and KYSE150 cell...
Kits to self-test for human papillomavirus (HPV) mailed to underserved women helped to identify virtually all of those with high-risk HPV oncogenic types, in a proof-of-principle study.Medscape Medical News
Although several new melanoma treatments have shown promise, none replaces surgery as the primary therapy yet, according to updated guidelines from the American Academy of Dermatology (AAD).Reuters Health Information
NCI ’ s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians.Air date: 2/22/2019 12:00:00 PM
Three female tech entrepreneurs shared their entrepreneurial journeys Monday evening, from dealing with self-doubt to running a business during breast cancer treatment. The local entrepreneurs who spoke as part of Global Entrepreneurship Week: Dr. Kim Gandy is CEO and founder of Play-it Health, which developed an adherence platform with incentives for transplant patients and those with chronic conditions. Linda Van Horn is CEO and founder of iShare Medical, wh ich provides secure, HIPAA-compliant…
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