The W-shaped ileal neobladder: Long term functional outcomes and health-related quality of life.

CONCLUSIONS: Our results suggest that voiding status and health-related quality of life remain satisfactory over ten years after an orthotopic ileal neobladder derivation. LEVEL OF EVIDENCE: 5. PMID: 27157921 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research

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Publication date: Available online 14 September 2019Source: Pharmacological ResearchAuthor(s): Rihui Wu, Xueting Mei, Yibiao Ye, Ting Xue, Jiasheng Wang, Wenjia Sun, Caixia Lin, Ruoxue Xue, Jiabao Zhang, Donghui XuAbstractZinc(II) complexes of curcumin display moderate cytotoxicity towards cancer cells at low micromolar concentrations. However, the clinical use of zinc(II) complexes is hampered by hydrolytic insolubility and poor bioavailability and their anticancer mechanisms remain unclear. Here, we investigated the efficacy and mechanism of action of a polyvinylpyrrolidone (PVP-k30)-based solid dispersion of Zn(II)-curc...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionsBoth 18F-HX4 and 18F-FMISO PET/CT can be used as biomarkers for tumor hypoxia and radiotherapy-associated changes. The clinical utilization of these two PET tracers needs to be further validated.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
HPV DNA detection in urine samples of women: "An efficacious and accurate alternative to cervical samples?" Expert Rev Anti Infect Ther. 2019 Sep 13;: Authors: Pattyn J, Van Keer S, Téblick L, Van Damme P, Vorsters A Abstract Cervical cancers are caused by persistent human papillomavirus (HPV) infections [1]. To date, HPV DNA testing using clinician-obtained cervical cells is the reference for identifying cervical infection. However, great interest has been shown for the use of self-sampling methods to detect HPV [2]. One method for self-sampling to be considered is the collection of f...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
ConclusionsPRDR radiation therapy with capecitabine were well tolerated and effective method for treating patients with recurrent breast cancer. Prospective studies are necessary to compare side effects and efficacy with conventional dose rate re-irradiation, as well as, to evaluate the potential role for capecitabine in the recurrent setting.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Abstract Two highly selective OFF-ON isomer fluorescent probes (1 and 2) for homo-/cysteine were designed and synthesized. The pyrene modified tetraphenylethylene derivative with AIE was used as luminescent group while maleimide was used as recognition group. These two isomer probes were found to be nearly nonfluorescent when treated with GSH. However, upon interaction with Cys or Hcy, the fluorescence was enhanced by 2000 folds in a wide pH range from 3 to 10. Experimental results and DFT calculation have demonstrated that the fluorescence OFF-ON switch of such thiol probes is resulted from the termination of the...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
vac D Abstract Metabolomics generate a profile of small molecules from plant extracts, which could be directly responsible for bioactivity effects. Using dry-column flash chromatography enabled a rapid and inexpensive method for the very efficient separation of plant extract with a high resolution. This separation method coupled to NMR and FTIR-based metabolomics is applied to identify bioactive natural products. OPLS multivariate analysis method, was used for correlation the chemical composition of the plant extracts, Amphoricarpos autariatus, with the results of cytotoxic activity against Human cervical adenocar...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Nocturnal incontinence (NI) after radical cystectomy (RC) and orthotopic neobladder (ONB) is a major problem that affects patients ’ health related quality of life. Pouch hyperactivity was reported in these patients with reported good response to short acting anticholinergic drugs. We aim to assess the effect of long acting anticholinergic drug in treatment of NI in a prospective randomized placebo- controlled study.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Bladder Cancer: Invasive IV Source Type: research
Conclusions: Nature contact may offer a range of human health benefits. Although much evidence is already available, much remains unknown. A robust research effort, guided by a focus on key unanswered questions, has the potential to yield high-impact, consequential public health insights. https://doi.org/10.1289/EHP1663 Received: 26 January 2017 Revised: 12 May 2017 Accepted: 25 May 2017 Published: 31 July 2017 Address correspondence to H. Frumkin, Dept. of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Box 354695, Seattle, WA 98195-4695 USA; Telephone: 206-897-1723;...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
Abstract: Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). We studied TLR7 expression in the bladder of patients with Hunner-type IC (HIC) and its functional roles in bladder inflammation and nociception using mice. Bladder biopsy specimens were obtained from patients with HIC. Specimens from the noncancerous portion of the bladder of patients with bladder cancer served as controls. The specimens were examined by immunohistochemistry and real-time polymerase chain reaction of TLR7. Loxor...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Increased mTORC1 signaling fromTSC1/TSC2 inactivation is found in cancer and causes tuberous sclerosis complex (TSC). The role of mesenchymal-derived cells in TSC tumorigenesis was investigated through disruption ofTsc2 in craniofacial and limb bud mesenchymal progenitors. Tsc2cKOPrrx1-cre mice had shortened lifespans and extensive hamartomas containing abnormal tortuous, dilated vessels prominent in the forelimbs. Abnormalities were blocked by the mTORC1 inhibitor sirolimus. A Tsc2/mTORC1 expression signature identified in Tsc2-deficient fibroblasts was also increased in bladder cancers withTSC1/TSC2 mutations in the TCGA...
Source: eLife - Category: Biomedical Science Tags: Cancer Biology Human Biology and Medicine Source Type: research
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