Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia

Conclusions Activated SC in PCa recapitulate the hallmarks of ‘reactive gliosis’ and contribute to analgesia due to suppression of spinal glia. Our findings propose a mechanism for how cancer might remain pain-free via the SC–central glia interplay during cancer progression.

http://gut.bmj.com/cgi/content/short/65/6/1001?rss=1

Source: Gut - May 9, 2016 Category: Gastroenterology Authors: Demir, I. E., Tieftrunk, E., Schorn, S., Saricaoglu, O. C., Pfitzinger, P. L., Teller, S., Wang, K., Waldbaur, C., Kurkowski, M. U., Wörmann, S. M., Shaw, V. E., Kehl, T., Laschinger, M., Costello, E., Algül, H., Friess, H., Ceyhan, G. O. Tags: Pancreas and biliary tract, Editor's choice, Pancreatic cancer Source Type: research