TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice

Conclusions
Intestinal epithelial TRAF6-dependent but MyD88/TRIF-independent and, thus, TLR-independent signalling pathways are critical for preventing propagation of DSS-induced colon inflammation by the gut microbiota. Moreover, our experiments using mice with dual MyD88/TRIF deletion in IECs unequivocally show that the gut microbiota trigger non-epithelial TLRs rather than epithelial TLRs to restrict DSS colitis severity.

Source: Gut - May 9, 2016 Category: Gastroenterology Authors: Vlantis, K., Polykratis, A., Welz, P.-S., van Loo, G., Pasparakis, M., Wullaert, A. Tags: Open access Experimental colitis Source Type: research