What Causes Pelvic Pain?
Discussion Appendicitis results from a closed loop obstruction of a blind-ending tubular structure arising from the cecum. It is a common cause of abdominal pain. It is the most frequent condition leading to emergent abdominal surgery in pediatrics. The combination of obstruction, edema, bacterial overgrowth, increased inflammatory process and increased intraluminal pressure leads to abdominal pain and possibly perforation. Appendicitis occurs in all age groups but is rare in neonates. The peak age is 6-10 years old. Pelvic inflammatory disease (PID) is an inflammatory disease of the uterus, fallopian tubes and adjacent pelvic structures caused by ascending microorganisms from the vagina and cervix particularly Neisseria gonorrhea and Chlamydia trachomatis. Increased risks for PID includes early age at first intercourse, multiple sexual partners, intrauterine device insertion and tobacco smoking. The Centers for Disease Control’s Sexually Transmitted Disease Treatment Guidelines can be found here. The causes of pelvic pain and abdominal pain necessarily overlap a great deal due to the proximity of anatomic structures as this case illustrates. Acute pelvic pain is defined as 6 months of noncyclic pain that is at the umbilicus or lower. Complete histories and good general physical examinations are important to guide the differential diagnosis. Pelvic examination may or may not be indicated. Laboratory testing especially to determine pregnancy status also helps guide di...
Conclusion: Elevated anxiety levels in patients undergoing coronary bypass surgery have a negative effect through prolonged QT and P-wave dispersion times. Anxiolytic treatment before surgery may be useful to prevent ventricular and atrial arrhythmias and associated complications through decreasing the QT and P-wave dispersion duration.
Authors: Karekar SR, Marathe PA Abstract Delamanid is a nitro-dihydro-imidazooxazole compound which was developed by a Japanese company, Otsuka Holdings inc. and has shown in-vitro and in-vivo activity against drug resistant tuberculosis. The drug exerts its anti-mycobacterial activity by inhibition of mycolic acid biosynthesis, leading to defective cell wall formation ultimately leading to bacterial death. Following the promising results in Phase 2 trials, Delamanid received approval in European Union in 2014, following which it was also approved in Japan and Korea in the same year. It was approved in India recent...
Authors: Das S, Sarkar R, Paul R, Bagri P, Dey A, Mukherjee A, Das A Abstract Background: Chronic inflammation in spondyloarthropathy (SpA) is associated with accelerated atherosclerotic cardiovascular disease (CVD). Flow mediated vasodilatation (FMD) and carotid intima-media thickness (cIMT) detects endothelial dysfunction and subclinical atherosclerosis respectively, responsible for atherosclerotic CVD. Objective: We aimed to examine the association of disease activity in SpA with surrogate markers of CVD, i.e., FMD and cIMT. Methods: Fifty patients of Axial SpA (Assessment of SpondyloArthritis Society-ASAS 2009 criteria) (
Conclusions: In healthy Indians ≥50 years, ZOSTAVAX was well tolerated and resulted in expected VZV-specific antibody titer levels at 6 weeks post-vaccination. PMID: 31325263 [PubMed - in process]
Conclusions: Botulinum toxin significantly decreases the severity of pain in PHN patients and last for 4-6 month of the period. This decrease is less prominent by passing time. PMID: 31325262 [PubMed - in process]
Conclusion: Septic CVT prognosis had better than non septic CVT. Hence, CVT presents with wide range of presentations and anticoagulation is the treatment. Septic CVT if intervened timely with proper antibiotics have better prognosis. Antibiotics are the mainstay of therapy for septic CVT. PMID: 31325261 [PubMed - in process]
Conclusion: KGMC index is best applicable to assess the osteoarthritis knee joint. Radiological progression in OA co-relates well with all clinical indices including KGMC index. This study highlights the usefulness of visual analogue scale and various radiological and clinical indices to assess osteoarthritis especially for knee joint. PMID: 31325259 [PubMed - in process]
Conclusion: Ensuring that anti-epilepsy drugs remain available in the public sector, and/or making them more affordable in the private sector are the main interventions likely to improve medication adherence in clinical settings such as ours. PMID: 31325256 [PubMed - in process]
Authors: Kumar SSS, Palaniandavan S, Bhargavi MV, Gambeer AS, Nithyalakshmi G Abstract Hashimoto's thyroiditis is a common form of chronic autoimmune thyroid disease (AITD) and it often coexists with other autoimmune diseases, but Hashimoto's thyroiditis associated with an autosomal dominant neurofibromatosis type 1 is exceedingly rare. A 30-year-old woman presented with complaints of headache for 1 year on and off. Physical examination revealed nodular swelling in the neck, cafe-au-lait spots, and neurofibromas covering the entire surface of her body. Her thyroid hormones were within normal limits. Thyroid ultraso...
Authors: Ravikirti, Sharma S Abstract Delamanid is a nitro-dihydro-imidazooxazole compound which was developed by a Japanese company, Otsuka Holdings inc. and has shown in-vitro and in-vivo activity against drug resistant tuberculosis. The drug exerts its anti-mycobacterial activity by inhibition of mycolic acid biosynthesis, leading to defective cell wall formation ultimately leading to bacterial death. Following the promising results in Phase 2 trials, Delamanid received approval in European Union in 2014, following which it was also approved in Japan and Korea in the same year. It was approved in India recently ...
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