The mechanism of the beneficial effect of botulinum toxin type A used in the treatment of temporomandibular joints dysfunction.

The mechanism of the beneficial effect of botulinum toxin type A used in the treatment of temporomandibular joints dysfunction.
Mini Rev Med Chem. 2016 May 6;
Authors: Malgorzata P, Piotr C, Edward K
Abstract
In the course of temporomandibular joint dysfunctions very often comes to excessive increase in tension of masticatory muscles, so main aim of the treatment is reduction of this hypertension of muscles. That why we use botulinum toxin type A, which is produced by Gram-positive Clostridium bacteria. There are six serotypes of the toxin: A, B, C, D, E, F, and G. The botulinum toxin type A was first isolated in 1920s. Today, botulinum toxin type A is used increasingly more often as an efficient and patient-friendly therapy in neurology, ophthalmology, neurology, urology and laryngology. The aim of the article was to make a review of the literature and description of the current knowledge concern with mechanism of action of botulinum toxin type A, clinical applications and metabolic determinants of muscle contraction and the beneficial effect of this drug on the state of muscle tension.
PMID: 27151142 [PubMed - as supplied by publisher]

Source: Mini Reviews in Medicinal Chemistry - May 5, 2016 Category: Chemistry Authors: Malgorzata P, Piotr C, Edward K Tags: Mini Rev Med Chem Source Type: research