Intrauterine growth restriction programs accelerated age-related increased cardiovascular risk in male offspring.

INTRAUTERINE GROWTH RESTRICTION PROGRAMS ACCELERATED AGE-RELATED INCREASED CARDIOVASCULAR RISK IN MALE OFFSPRING. Am J Physiol Renal Physiol. 2016 May 4;:ajprenal.00123.2016 Authors: Dasinger JH, Intapad S, Backstrom MA, Carter AJ, Alexander BT Abstract Placental insufficiency programs an increase in blood pressure associated with a two-fold increase in serum testosterone in male growth-restricted offspring at 4 months of age. Population studies indicate that the inverse relationship between birth weight and blood pressure is amplified with age. Thus, we tested the hypothesis that intrauterine growth restriction programs an age-related increase in blood pressure in male offspring. Growth-restricted offspring retained a significantly higher blood pressure at 12 but not at 18 months of age compared to age-matched controls. Blood pressure was significantly increased in control offspring at 18 months of age relative to control counterparts at 12 months; however, blood pressure was not increased in growth-restricted at 18 months relative to growth-restricted counterparts at 12 months. Serum testosterone levels were not elevated in growth-restricted offspring relative to control at 12 months of age. Thus, male growth-restricted offspring no longer exhibited a positive association between blood pressure and testosterone at 12 months of age. Unlike hypertension in male growth-restricted offspring at 4 months of age, inhibition of the renin a...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research