Diversities of Calreticulin Gene Mutations in Macedonian Patients with Essential Thrombocythemia

A wide range of different CALR mutations were detected in 150 Macedonian patients with essential thrombocythemia which were associated with distinct clinical phenotype with a milder clinical course of the disease compared to patients with JAK2 V617F mutation. Polymerase chain reaction /capillary electrophoresis is the method of choice for the analysis of CALR mutations.

Source: Clinical Lymphoma, Myeloma and Leukemia - May 4, 2016 Category: Hematology Authors: Irina Panovska-Stavridis, Aleksandar Eftimov, Martin Ivanovski, Aleksandar Stojanovik, Borce Georgievski, Lidija Cevreska, Aleksandar J. Dimovski Tags: Original Study Source Type: research