Coupling end resection with the checkpoint response at DNA double-strand breaks.

Coupling end resection with the checkpoint response at DNA double-strand breaks.
Cell Mol Life Sci. 2016 May 3;
Authors: Villa M, Cassani C, Gobbini E, Bonetti D, Longhese MP
Abstract
DNA double-strand breaks (DSBs) are a nasty form of damage that needs to be repaired to ensure genome stability. The DSB ends can undergo a strand-biased nucleolytic processing (resection) to generate 3'-ended single-stranded DNA (ssDNA) that channels DSB repair into homologous recombination. Generation of ssDNA also triggers the activation of the DNA damage checkpoint, which couples cell cycle progression with DSB repair. The checkpoint response is intimately linked to DSB resection, as some checkpoint proteins regulate the resection process. The present review will highlight recent works on the mechanism and regulation of DSB resection and its interplays with checkpoint activation/inactivation in budding yeast.
PMID: 27141941 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - May 2, 2016 Category: Cytology Authors: Villa M, Cassani C, Gobbini E, Bonetti D, Longhese MP Tags: Cell Mol Life Sci Source Type: research