Regulation of actin nucleation and autophagosome formation.

Regulation of actin nucleation and autophagosome formation.
Cell Mol Life Sci. 2016 May 4;
Authors: Coutts AS, La Thangue NB
Abstract
Autophagy is a process of self-eating, whereby cytosolic constituents are enclosed by a double-membrane vesicle before delivery to the lysosome for degradation. This is an important process which allows for recycling of nutrients and cellular components and thus plays a critical role in normal cellular homeostasis as well as cell survival during stresses such as starvation or hypoxia. A large number of proteins regulate various stages of autophagy in a complex and still incompletely understood series of events. In this review, we will discuss recent studies which provide a growing body of evidence that actin dynamics and proteins that influence actin nucleation play an important role in the regulation of autophagosome formation and maturation.
PMID: 27147468 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - May 3, 2016 Category: Cytology Authors: Coutts AS, La Thangue NB Tags: Cell Mol Life Sci Source Type: research