Antibody Appears to Attack Cancer Cells, Leaving Other Cells Unscathed

Contact: Sarah Avery Phone: 919-660-1306 Email: EMBARGOED FOR RELEASE until 12 p.m. noon (ET) on Thursday, May 5, 2016 DURHAM, N.C. -- A research team from Duke Health has developed an antibody from the body’s own immune system that preferentially attacks cancer cells. The antibody works by targeting a natural defense mechanism that cancer tumors exploit. Cells in the body essentially use a home security system that relies on certain proteins to protect the cell surface and keep it safe. These proteins help the cell avoid injury and even death from unwanted activation of the immune system. In a paper published online May 5 in Cell Reports, the Duke team describes the workings of a cancer-fighting antibody they discovered, developed and tested in cell lines and animal models. The antibody dismantles a specific part of a cancer cell’s defense system and then employs several mechanisms of attack. "This is the first completely human-derived antibody developed as an anti-cancer therapy, which is very different from other immunotherapy approaches,” said senior author Edward F. Patz, Jr., M.D., the James and Alice Chen Professor of Radiology and professor in the Department of Pharmacology and Cancer Biology at Duke. Patz and colleagues -- including principals from the Duke Human Vaccine Institute who have been advancing the development of antibodies for an HIV vaccine -- started with the observation that some lun...
Source: Duke Health Features - Category: Pediatrics Tags: Duke Medicine Source Type: news

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In conclusion, HOXD-AS1 may be considered as a promising diagnostic/prognostic biomarker or a novel therapeutic target for cancers.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
In conclusion, HOXD-AS1 may be considered as a promising diagnostic/prognostic biomarker or a novel therapeutic target for cancers. PMID: 30290157 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Tags: Clin Chim Acta Source Type: research
ConclusionsThis cohort experienced an excess in the incidence of both mesothelioma and lung cancer, showing increasing incidence rates at higher level of asbestos exposure. For lung cancer, the relative incidence was highest among workers hired in shipbuilding between 1974 and 1984.
Source: International Archives of Occupational and Environmental Health - Category: Occupational Health Source Type: research
Conclusion: The current study elucidated the prevalence of HBV and HCV among large population of solid cancers and lymphoma and we showed that hepatitis B and C positivity rates are significantly increased in certain solid tumors. Our findings should also be clarified with large prospective studies.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
OBJECTIVES: Cancer in young adults represents a great challenge, both biologically and socially, and understanding the unique characteristics of neoplasms in this age group is important to improving care. We aimed to evaluate the most common carcinomas and their characteristics, such as histological type and clinical stage, in young adults in the largest cancer hospital in Latin America. METHODS: The hospital registry was consulted for the period between 2008 and 2014. Young adults were defined as individuals aged 18 to 39 years, and older adults were defined as individuals aged 40 years and older. Differences between age ...
Source: Clinics - Category: General Medicine Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Overexpression of Epsin 3 enhances migration and invasion of glioma cells by inducing epithelial‑mesenchymal transition. Oncol Rep. 2018 Sep 10;: Authors: Wang Y, Song W, Kan P, Huang C, Ma Z, Wu Q, Yao X, Zhang B Abstract Epsin 3 (EPN3) expression is limited to gastric parietal cells and wounded or pathological tissue rather than normal brain tissue, and although it has been identified as an oncogene in estrogen receptor‑positive breast cancer and non‑small cell lung cancer, its function in cancer is poorly understood. The present study aimed to investigate the association of EPN3 expr...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
In conclusion, results of the present study demonstrated that LINC00978 exerts an oncogenic role in NSCLC by inhibiting miR‑6754‑5p expression. PMID: 30221669 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Nearly 10 million people around the world will die of cancer this year, according to new estimates from the World Health Organization’s International Agency for Research on Cancer (IARC). The IARC’s report, which was published Wednesday in CA: A Cancer Journal for Clinicians, was based on cancer incidence data from 185 countries around the world. Researchers estimated that there will be 18.1 million new diagnoses of cancer and 9.6 million cancer deaths in 2018. Those numbers — a marked increase from just six years ago, when cancer diagnoses were estimated at 14.1 million, and deaths at 8.2 million —...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime Innovation Health Source Type: news
(CNN) — The number of people around the world who have cancer is “rapidly growing,” with 18.1 million new cases and 9.6 million deaths in 2018 alone, researchers estimate in a new report. By the end of the century, cancer will be the No. 1 killer globally and the single biggest barrier to increasing our life expectancy, according to the report, released Wednesday by the World’s Health Organization’s International Agency for Research on Cancer. Cancer by the numbers The researchers used data from 185 countries, looking at all the places in the body cancer can occur and taking a deeper look at 3...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Cancer Local TV Source Type: news
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