CXCL3 is a Potential Target for Breast Cancer Metastasis.

CXCL3 is a Potential Target for Breast Cancer Metastasis.
Curr Cancer Drug Targets. 2014 Mar 5;
Authors: See AL, Chong PK, Lu SY, Lim YP
Abstract
Secreted proteins are an attractive minefield for cancer drug targets. An iTRAQ-based tandem mass spectrometry approach was employed to relatively quantify proteins in the secretomes of four isogenic breast cancer cell lines with increasing metastatic potential. CXCL3 was found to be upregulated in aggressive cancer cells. SiRNA and antibody neutralization studies supported a role of CXCL3 in metastatic processes. Meta-analysis of the mRNA level of CXCL3 in 1881 breast tumors supported a role of CXCL3 in clinical breast cancer. Our results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy.
PMID: 24605943 [PubMed - as supplied by publisher]

Source: Current Cancer Drug Targets - March 5, 2014 Category: Cancer & Oncology Authors: See AL, Chong PK, Lu SY, Lim YP Tags: Curr Cancer Drug Targets Source Type: research