The Impact of Experiencing Adverse Drug Reactions on the Patient’s Quality of Life: A Retrospective Cross-Sectional Study in the Netherlands

The objective of this study was to explore the impact of ADRs on HR-QOL in patients who reported a possible ADR to Lareb in relation to the change in the packaging of the drug Thyrax®. A secondary objective was to explore factors correlated with change in HR-QOL. Methods Patients who reported an ADR in relation to the Thyrax® packaging change were included in this study. A web-based adapted version of the COOP/WONCA questionnaire was sent to explore the HR-QOL before versus during the ADR, expressed on a 5-point scale from no impact (1) to high impact (5). Multivariable linear regression analysis was used to identify factors correlated with change in HR-QOL. Results Overall, 1167 patients returned the questionnaire (71.2 % response rate). The difference in HR-QOL was −0.8 for physical, −1.2 for mental, −1.4 for daily activities, −1.3 for social, and −1.3 for overall health status (p 
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 6 April 2020Source: Clinica Chimica ActaAuthor(s): Julia L. Varghese, Angela W.S. Fung, Andre Mattman, Tien T.T. Quach, Deonne Thaddeus V. Gauiran, Mollie N. Carruthers, Luke Y.C. Chen
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Authors: Pappas-Gogos G, Baltagiannis EG, Kyrochristos ID, Ziogas DE, Goussia A, Mitsis M, Roukos DH PMID: 32250157 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Authors: Esteves JV, Yonamine CY, Machado UF PMID: 32250156 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Authors: Nazemalhosseini-Mojarad E, Sanjabi F, Babini H PMID: 32250155 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Authors: Thomsen CB, Jakobsen A PMID: 32250154 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
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