R‐and S‐citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation

CONCLUSIONSOur results suggest that citalopram enantiomers contributed differentially to treatment outcomes. (R)‐citalopram accounted for a greater proportion of the adverse consequences associated with racemic citalopram treatment in patients with AD including a decreased probability of treatment response as measured by the CGIC and a reduction in MMSE scores. The S‐enantiomer was associated with increased probability of response based on the CGIC.

Source: British Journal of Clinical Pharmacology - May 3, 2016 Category: Drugs & Pharmacology Authors: T. Ho, B. G. Pollock, B. H. Mulsant, O. Schantz, D. P. Devanand, J. E. Mintzer, A. P. Porsteinsson, L. S. Schneider, D. Weintraub, J. Yesavage, L. T. Drye, C. A. Munro, D. M. Shade, C. Lyketsos, R. Bies Tags: Pharmacokinetic Dynamic Relationships Source Type: research