Oxidative stress protection by manganese complexes of tail-tied aza-scorpiand ligands.

Oxidative stress protection by manganese complexes of tail-tied aza-scorpiand ligands. J Inorg Biochem. 2016 Apr 16; Authors: González-García J, Martínez-Camarena À, Verdejo B, Clares MP, Soriano C, García-España E, Jiménez HR, Doménech-Carbó A, Tejero R, Calvo E, Briansó-Llort L, Serena C, Trefler S, Garcia-España A Abstract The Mn(2+) coordination chemistry of double scorpiand ligands in which two polyazacyclophane macrocycles have been connected by pyridine, phenanthroline and bipyridine spacers has been studied by potentiometry, paramagnetic NMR and electrochemistry. All ligands show high stability with Mn(2+) and the complexes were formed in a wide pH range. DFT calculations support the structures and coordination geometries derived from the study. A remarkable antioxidant activity was evidenced for these systems by the McCord-Fridovich assay and in Escherichiacoli sodAsodB deficient bacterial cells. The three systems were tested as anti-inflammatory drugs in human macrophages measuring the accumulation of cytokines upon lipopolysaccharide (LPS) pro-inflammatory effect. All complexes showed anti-inflammatory effect, being [Mn2L1](4+) the most efficient one. PMID: 27133803 [PubMed - as supplied by publisher]
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research