CardioBrief: Rosuvastatin Goes Generic, Major Role Expected

(MedPage Today) -- Finally there's a challenger to the long reign of atorvastatin, experts say
Source: MedPage Today Public Health - Category: American Health Source Type: news

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Adele Chimento, Ivan Casaburi, Paola Avena, Francesca Trotta, Arianna De Luca, Vittoria Rago, Vincenzo Pezzi, Rosa Sirianni
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
A portion of this article was previously published as part of an article titled “Human C-reactive protein and the metabolic syndrome” in the following journal: Curr Opin Lipidol. 2009 Jun;20(3):182-9.
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
In this study, scientists screened cells from old animals to identify any RBPs that change upon aging. The screening showed that one particular protein, Pumilio2 (PUM2), was highly induced in old animals. PUM2 binds mRNA molecules containing specific recognition sites. Upon its binding, PUM2 represses the translation of the target mRNAs into proteins. Using a systems genetics approach, the researchers then identified a new mRNA target that PUM2 binds. The mRNA encodes for a protein called Mitochondrial Fission Factor (MFF), and is a pivotal regulator of mitochondrial fission - a process by which mitochondria break u...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(Natural News) Heart disease might sound like it’s practically inevitable, with 17.3 million people dying from it each year – a number that is projected to exceed 23.6 million by the year 2030. However, you actually have far more control over it than you think – and you don’t need to take statins or aspirin...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
This article is protected by copyright. All rights reserved. PMID: 30659590 [PubMed - as supplied by publisher]
Source: Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Pharmacol Ther Source Type: research
ConclusionsThis study identified the expected GIB risk with warfarin compared with statins using an analytic tool developed for Sentinel. Our findings suggest that comparators with different indications may be useful in surveillance in select circumstances. Finally, in the presence of differential censoring, stratification by matched pair may reduce the potential for bias in Cox regression analyses.
Source: Pharmaceutical Medicine - Category: Drugs & Pharmacology Source Type: research
Authors: Khadir A, Kavalakatt S, Dehbi M, Alarouj M, Bennakhi A, Tiss A, Elkum N Abstract Background: Cardiovascular disease (CVD) risks persist in patients despite the use of conventional treatments. This might be due to chronic inflammation as reflected in epidemiological studies associating circulating low-grade inflammatory markers with CVD recurrent events. Here, we explored this potential link by assessing plasma dual-specificity phosphatase 1 (DUSP1) levels and comparing them to high-sensitivity CRP (hsCRP) and oxidized low-density lipoprotein (oxLDL) levels and their associations to conventional CVD risk fa...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Publication date: March 2019Source: Pharmacological Research, Volume 141Author(s): Yafei Chen, Xiaoli Li, Rui Zhang, Yuhong Xia, Zhuo Shao, Zubing MeiAbstractStatin exposure has been reported to improve survival in several cancers. However, studies evaluating the association between statins and prognostic outcomes in patients with lung cancer are conflicting and heterogeneous. Pubmed, EMBASE and reference lists of included studies were searched to identify studies investigating the association between statin exposure and lung cancer prognosis. The primary outcome measure was overall survival (OS) and secondary ones include...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Authors: Klug E, Raal FJ, Marais AD, Smuts CM, Schamroth C, Jankelow D, Blom DJ, Webb DA Abstract South Africa (SA) is home to a heterogeneous population with a wide range of cardiovascular risk factors. Cholesterol reduction in combination with aggressive management of modifiable risk factors, including nutrition, physical activity, blood pressure and smoking, can help to reduce and prevent morbidity and mortality in individuals who are at increased risk of cardiovascular events. This updated consensus guide to management of dyslipidaemia in SA is based on the updated European Society of Cardiology and European At...
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
“Mrs. Jones, based on your risk factors for having a heart attack, I recommend that we start you on a statin.”
Source: International Journal of Cardiology - Category: Cardiology Source Type: research
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