Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria

Conclusion: PH1 Ur-PROs reflected overt inflammation, chemotaxis, oxidative stress, growth factors (including EGF), and pro-angiogenic and calcification regulation/inhibition compared to the C and IHC cohorts. Many of the up- and downregulated PH1-PROs found in this study are also found in CKD, acute kidney injury, stone formers, and/or stone matrices. Further data analyses may provide evidence for PH1 unique PROs or demonstrate a poorer clinical outcome.Am J Nephrol 2016;43:293-303
Source: American Journal of Nephrology - Category: Neurology Source Type: research