MAD2B-mediated SnoN Downregulation Is Implicated in Fibroblast Activation and Tubulointerstitial Fibrosis.

In conclusion, our observation proposes that besides cell cycle management MAD2B has a profibrotic role during fibroblast activation and TIF by suppressing SnoN expression. Targeting MAD2B-SnoN pathway is a promising intervention for TIF. PMID: 27122545 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/27122545?dopt=Abstract

Source: Am J Physiol Renal P... - April 26, 2016 Category: Urology & Nephrology Authors: Tang H, Su H, Fan D, Ye C, Lei CT, Jiang HJ, Gao P, He FF, Zhang C Tags: Am J Physiol Renal Physiol Source Type: research

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