Rigenera protocol in the treatment of surgical wound dehiscence
In conclusion, although we reported only three patients, autologous micro‐grafts can be considered a promising approach for the treatment of dehisced wounds, improving the wound‐healing process and in general the patient's quality of life without using other dressings.
Macrophages are important in mounting an innate immune response to injury as well as in repair of injury. Gene expression of Rho proteins is known to be increased in fibrotic models; however, the role of these proteins in idiopathic pulmonary fibrosis (IPF) is not known. Here, we show that BAL cells from patients with IPF have a profibrotic phenotype secondary to increased activation of the small GTPase Rac1. Rac1 activation requires a posttranslational modification, geranylgeranylation, of the C-terminal cysteine residue. We found that by supplying more substrate for geranylgeranylation, Rac1 activation was substantially ...
T cell autoreactivity is a hallmark of autoimmune diseases but can also benefit self-maintenance and foster tissue repair. Here, we investigated whether heart-specific T cells exert salutary or detrimental effects in the context of myocardial infarction (MI), the leading cause of death worldwide. After screening more than 150 class II–restricted epitopes, we found that myosin heavy chain α (MYHCA) was a dominant cardiac antigen triggering post-MI CD4+ T cell activation in Balb/c mice. Transferred MYHCA614–629-specific CD4+ T cells (TCR-M cells) selectively accumulated in the myocardium and mediastinal lym...
Cardiac tissue necrosis secondary to coronary artery occlusion is one of the most common and deadly sterile injuries in developed countries. In this issue of the JCI, Rieckmann et al. identified and characterized antigen-specific CD4+ T helper (Th) cells that developed in the context of myocardial infarction (MI) in mice. They showed that myosin heavy chain α (MYHCA) is a dominant cardiac autoantigen and that T cells with T cell receptor (TCR) specificity to MYHCA acquired a Treg phenotype when adoptively transferred into infarcted mice, which mediated a cardioprotective healing response. Thus, Rieckmann et al. showe...
To show the repair of an uncommon urogynecological pathology, and to illustrate a case where an autologous fascial graft is placed for management of stress urinary incontinence.
To illustrate the use of robotic-assisted laparoscopy with simultaneous hysteroscopy for the repair of an isthmocele.
The objective of this video is to review the definition, diagnosis, consequences of an uterine isthmocele. This video also demonstrates surgical management of isthmoceles using a combination of laparoscopy and hysteroscopy.
This video demonstrates the technique for a Robotic assisted laparoscopic repair of a large Isthmocele.
To demonstrate the utility of the Martius Labial Fat Pad Graft in pelvic fistula repair.
We present a case of patient affected by diaphragmatic endometriosis who was treated by laparoscopy.
This video demonstrates the repair of a high rectovaginal fistula done laparoscopically.