Log in to search using one of your social media accounts:

 

Cancer and Autism LinkedCancer and Autism Linked

A paradoxical increase in oncogenic mutations, but a markedly reduced cancer risk in individuals with autism, may lead to cancer therapies being 'repurposed' to treat autism, say US scientists. Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry News Source Type: news

Related Links:

The MEF2 polypeptide C (MEF2C), a transcription factor, encodes for a protein that plays a key role in myogenesis, craniofacial development, and neurogenesis. In 2010, microarray studies identified a microdeletion of 5q14.3 region (critical region including the MEF2C gene) to be contributing to a phenotype including intellectual disability, epilepsy and other cerebral malformations. Both truncating single nucleotide variations and deletions of this gene demonstrate haploinsuffciency. Clinically, MEF2C-related disorders are characterized by severe intellectual disability with absent speech, autism, limited walking abilities...
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research
This report would examine developments at the state and federal-level, court cases, and current views from stakeholders. Policy Questions Which states have PAS laws and what do those laws provide? What protections against abuse of PAS?What have the Supreme Court and lower courts held regarding individuals’ rights under PAS laws? The laws themselves?Is there evidence that persons with disabilities are being denied treatment by insurance companies but offered PAS instead, as NCD predicted?How is PAS viewed by disability organizations? Has this evolved in the past 13 years? If so why? If not, why?Are persons with disabi...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs
Phosphatase and tensin homolog (PTEN) is a tumor suppressor frequently mutated in diverse cancers. Germline PTEN mutations are also associated with a range of clinical outcomes, including PTEN hamartoma tumor syndrome (PHTS) and autism spectrum disorder (ASD). To empower new insights into PTEN function and clinically relevant genotype-phenotype relationships, we systematically evaluated the effect of PTEN mutations on lipid phosphatase activity in  vivo. Using a massively parallel approach that leverages an artificial humanized yeast model, we derived high-confidence estimates of functional impact for 7,244 single ami...
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Abstract DICER1 encodes an RNase III endonuclease protein that regulates the production of small non-coding RNAs. Germline mutations in DICER1 are associated with an autosomal dominant hereditary cancer predisposition syndrome that confers an increased risk for the development of several rare childhood and adult-onset tumors, the most frequent of which include pleuropulmonary blastoma, ovarian sex cord-stromal tumors, cystic nephroma, and thyroid gland neoplasia. The majority of reported germline DICER1 mutations are truncating sequence-level alterations, suggesting that a loss-of-function type mechanism drives tu...
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
The prevalence of infertility in the United States is estimated to be 7-15%. There has been conflicting data in regard to the health outcomes of offspring born to infertile couples and follow up of offspring can be challenging. As such, longer term health outcomes of these offspring remain uncertain. We sought to determine the impact of infertility in male and females on their offspring in various categories.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infertility: Epidemiology & Evaluation I Source Type: research
DiscussionEarly onset psychosis is associated with poor long term outcomes in a portion of patients, although current functional outcomes in these patients may be comparatively better in relation to data from historical reports (Clemmensen 2012). Factors related to improved healthcare services, such as reduction in duration of untreated psychosis and new treatment modalities may potentially underlie these differences.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research
Mutation of either TSC1 or TSC2 causes tuberous sclerosis, a multisystem genetic syndrome that can lead to formation of benign tumors in the kidneys, lungs, and other organs and has also been linked to epilepsy and autism. The tumor suppressors Tsc1 and Tsc2 form the tuberous sclerosis complex (TSC), a regulator of mTOR activity. Tsc1 stabilizes Tsc2; however the precise mechanism remains elusive. Molecular chaperones such as heat shock protein-90 (Hsp90) are essential for the stability and activation of numerous signaling proteins, including tumor suppressors.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Kidney Cancer: Basic Research & Pathophysiology III Source Type: research
The engineered β-lactoglobulin with complementarity to the chlorpromazine chiral conformers. Int J Biol Macromol. 2018 Mar 16;: Authors: Loch JI, Bonarek P, Tworzydło M, Łazińska I, Szydłowska J, Lipowska J, Rzęsikowska K, Lewiński K Abstract Chlorpromazine (CPZ) is a phenothiazine acting as dopamine antagonist. Aside from application in schizophrenia therapy, chlorpromazine is found to be a putative inhibitor of proteins involved in cancers, heritable autism disorder and prion diseases. Four new β-lactoglobulin variants with double or triple substitutions: I56F/L39A, F105L/L39A, I56F/...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Left-handedness, as a relatively uncommon phenomenon, never fails to fascinate people. There is a common perception that left-handed people are more talented and artistic. To what extent these assumptions are correct, and what your preferred use of right or left hand can tell you about your brain structure? Handedness represents the better performance or preference of using one hand, i.e., the dominant hand. Right-handedness is the most common type observed in 70–95% of the world population, followed by left-handedness, and then a very rare type of mixed handedness and ambidexterity. Although this is an important ph...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Brain Blogger Publishers Brain Structure Handedness left-handed right-handed Source Type: blogs
Romidepsin, a compound that is already approved for treating cancer, reversed social deficits in a mouse model of autism by restoring gene expression.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Autism Source Type: news
More News: Autism | Cancer | Cancer & Oncology | Cancer Therapy | Psychiatry