Cancer and Autism LinkedCancer and Autism Linked

A paradoxical increase in oncogenic mutations, but a markedly reduced cancer risk in individuals with autism, may lead to cancer therapies being 'repurposed' to treat autism, say US scientists. Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry News Source Type: news

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Authors: Grant WB Abstract Vitamin D, traditionally well known for its role in maintaining optimal health through its contribution to calcium metabolism and skeletal health, has received increased attention over the past two decades, with considerable focus being placed on its nonskeletal benefits. This paper is a narrative review of the nonskeletal health benefits of vitamin D, of particular interest to inhabitants of Mediterranean countries, namely, autism, cancer, cardiovascular disease, chronic obstructive pulmonary disease, dental caries, diabetes mellitus, erectile dysfunction, hypertension, metabolic syndrom...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
When Nichelle Obar learned she was pregnant with her second child last year, she never expected that her pregnancy, or her baby, would make history. But when the 40-year-old food-and-beverage coordinator from Hawaii and her fiancé Christopher Constantino went to their 18-week ultrasound, they learned something was wrong. The heart was larger than it should have been, and there was evidence that fluid was starting to build up around the organ as well. Both were signs that the fetus was working extra hard to pump blood to its fast-growing body and that its heart was starting to fail. Obar’s doctor knew what coul...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized medicine Source Type: news
Conclusion: Most never-smokers with lung cancer do not respond to immune checkpoint inhibitors (ICIs). But for unknown reasons, a small proportion do show clinical benefit from the ICI pembrolizumab. Because of the good response of this group, it may be worthwhile assessing their SLC18A1 expression pre-treatment as a marker for potential clinical benefit. If SLC18A1 expression is low, a never-smoker may respond well to ICIs. High levels of expression would indicate a C5 tumor less likely to respond to ICIs. SLC18A1 might complement other biomarkers currently under study in relation to programmed cell death protein 1/progra...
Source: Cancer Genomics and Proteomics - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
More research is done on the therapeutic benefits of dogs than on cats and other animals. But there are signs of change.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Animal Behavior Service Dogs and Other Animals Cats Therapy and Rehabilitation Post-Traumatic Stress Disorder Autism Mental Health and Disorders Cancer Breast Cancer Source Type: news
(University of Texas at Arlington) UTA biochemists are mapping the function of specific enzymes which may facilitate development of new drugs to fight bacterial infection, cancer and potentially neurodegenerative diseases like autism, Down syndrome, Parkinson's disease and Alzheimer's.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(AKSON Russian Science Communication Association) The team studied a family of proteins that includes MCT-1, which is a product of an oncogene (a gene that can trigger tumour formation); its partner DENR, which is associated with autism; and the translation factor elF2D. As a result, they have found out that factors eIF2D, MCT-1 and DENR are required for the ribosome to detach timely from the mRNA once the translation is complete.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
(New York Genome Center) Researchers at the New York Genome Center (NYGC) and Columbia University have uncovered a molecular mechanism behind one of biology's long-standing mysteries: why individuals carrying identical gene mutations for a disease end up having varying severity or symptoms of the disease. The study has exciting implications for future prediction of the severity of serious diseases such as cancer and autism spectrum disorder.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsWe provide pharmacological profiles of indenoisoquinoline-derived Top1 inhibitors as paternalUbe3a unsilencers. All 13 tested compounds were effective at unsilencing paternalUbe3a, although with variable efficacy and potency. Indotecan (LMP400) demonstrated a better pharmacological profile ofUbe3a unsilencing compared to our previous lead compound, topotecan. Taken together, indotecan and its structural analogues are potential AS therapeutics whose translational potential in AS treatment should be further assessed.
Source: Molecular Autism - Category: Molecular Biology Source Type: research
Abstract The 21st century has witnessed the discovery of multiple rare and common gene variants associated with attention deficit hyperactivity disorder (ADHD), and these discoveries have already provided a starting point for the investigation of the biology of the disorder and novel treatments. The purpose of this selective review is to examine genetic findings from the past 5 years and consider their implications for the conceptualization of ADHD and future clinical practice. Recent discoveries reveal the strong genetic overlaps between ADHD and autism spectrum disorder (ASD) as well as intellectual disability. ...
Source: The American Journal of Psychiatry - Category: Psychiatry Authors: Tags: Am J Psychiatry Source Type: research
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