40 Isn't the New 30 When It Comes to Your Ovaries

This report did acknowledge that delayed initial child-bearing in the U.S. has most definitely contributed to the increase in the mean age of a woman having her first child. The report also commented that an increase in "delayed initial childbearing can affect the number of children a typical woman will have in her lifetime, family size, and for the overall population change in the United States." Women are starting families later in life AND having more babies after age 35, that age that when a woman medically becomes "advanced maternal age", and even after age 40. Because of this report, many social media sites and notable news outlets have even suggested that the biological clock is a thing of the past. A woman can wait until she is darn good and ready to have a baby. She can pursue her career or other life goals and have a family when she is "settled" at age 35 or older. So rest easy, "mature" woman. You CAN wait! WARNING! The ovary begs to differ... A decision to delay child-bearing for ANY reason does NOT mean the ovary will delay the aging process. The fact remains that the internal biological clock continues to tick, i.e., the ovary marches on despite the fact that a woman has decided to wait. This means that women delaying child-bearing until their late 30s and 40s will still be faced with decreasing egg quantity (the number of eggs available for fertilization with each menstrual cycle) and egg quality (the number of availa...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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ConclusionsPsA patients do not have more infertility or worse pregnancy outcomes compared to healthy controls.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 6 December 2018Source: African Journal of UrologyAuthor(s): M.S. Abdel-Kader, A.M. Hassan, M. AbdelRazekAbstractObjectivesTo compare the results of unilateral and bilateral subinguinal varicocelectomy for patients with primary infertility, including sperm parameters and pregnancy rate.Patients and methodThis a retrospective study including 91 men with primary subfertility with bilateral varicocelectomy. The patients were divided into two groups. Group A (46 patients) were subjected to bilateral varicocelectomy. Group B (45 patients) subjected to left varicocelectomy. Patients with unilate...
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research
We describe, to our knowledge, the first case worldwide of livebirth following uterine transplantation from a deceased donor in a patient with MRKH syndrome. The results establish proof-of-concept for treating uterine infertility by transplantation from a deceased donor, opening a path to healthy pregnancy for all women with uterine factor infertility, without need of living donors or live donor surgery.FundingFundação de Amparo à Pesquisa do Estado de São Paulo and Hospital das Clínicas, University of São Paulo, Brazil.
Source: The Lancet - Category: General Medicine Source Type: research
In my experience, most people dealing with infertility would say that their longing for a child brings sadness year-round. Still, there are times and seasons when the pain intensifies. This may be in spring or early summer when the world is in bloom, winter coats are off and pregnant bellies are out, when greeting card companies and florists ambush airwaves to promote Mother’s Day and Father’s Day. Similarly, the winter holidays present an ever-lengthening stretch during which many women and men who are struggling with infertility feel pummeled. Bookended by Thanksgiving and New Year’s, this has become a ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infertility Source Type: blogs
A novel transplantation procedure may help more infertile women become pregnant.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Uterus Transplants Pregnancy and Childbirth Infertility Lancet, The (Journal) Brazil Source Type: news
The world’s first baby born by a uterus transplant from a deceased donor is healthy and nearing her first birthday, according to a new case study published Tuesday in the Lancet. Uterus transplants have become more common in recent years, resulting in 11 live births around the world. But all of the other successful deliveries so far have been made possible by living donors — often women who opt to donate their uterus to a close friend or family member without one. The birth resulting from the case detailed in the Lancet, which took place at Brazil’s Hospital das Cli╠ünicas last December, is both the first...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized fertility healthytime Source Type: news
In this study, we focus on the effect of alterations in the expression of the AKT/AMPK/mTOR signalling pathway in mouse uterine tissue after embryo loss induced by harmful environmental exposure to carbon disulfide (CS2). CS2 is a material used in certain production processes, and women are sometimes exposed to it in occupational settings. We created an animal model of gestating mice exposed to CS2 on gestation days 3 (GD3), 4 (GD4), 5 (GD5) and 6 (GD6) with various corresponding endpoints after the exposure. The uterine tissue was collected according to the endpoint time series to detect the expression levels of mTOR, p-m...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
In this study, we focus on the effect of alterations in the expression of the AKT/AMPK/mTOR signalling pathway in mouse uterine tissue after embryo loss induced by harmful environmental exposure to carbon disulfide (CS2). CS2 is a material used in certain production processes, and women are sometimes exposed to it in occupational settings. We created an animal model of gestating mice exposed to CS2 on gestation days 3 (GD3), 4 (GD4), 5 (GD5) and 6 (GD6) with various corresponding endpoints after the exposure. The uterine tissue was collected according to the endpoint time series to detect the expression levels of mTOR, p-m...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
Much research over recent years has centered on whether assisted reproductive technology (ART) pregnancies, those that arise after manipulation of eggs and embryos in  vitro, result in adverse outcomes for women and children. The underlying assumption of this research has been that the ART treatment, the underlying infertility, or a combination of the two are responsible for the adverse pregnancy, obstetric, delivery, and neonatal outcomes that have been documen ted. Far fewer studies have attempted to document the contribution of the male partner to these observations.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Condition:   Infertility Interventions:   Drug: Nolasiban;   Drug: Placebo Sponsor:   ObsEva SA Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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