Three new 3-methyl-2-arylbenzofurans from the fermentation products of an endophytic fungus Phomopsis sp. and their anti-TMV activity

Publication date: Available online 26 April 2016 Source:Phytochemistry Letters Author(s): Gang Du, Zhong-Cheng Wang, Wei-Yao Hu, Ke-Liang Yan, Xin-Lin Wang, Hong-Mei Yang, Hai-Ying Yang, Yu-Hong Gao, Qiang Liu, Qiu-Fen Hu Three new arylbenzofurans, 7-methoxy-2-(4-methoxyphenyl)-3-methyl-5-(3-prenyl)-benzofuran (1), 2-(4-methoxyphenyl)-3-methyl-5-(3-prenyl)-benzofuran-7-ol (2), 2-(4-hydroxy-3,5-dimethoxyphenyl)-3-methyl-5-(3-prenyl)benzofuran-7-ol (3), along with four known arylbenzofurans (4–7) were isolated from the fermentation products of an endophytic Phomopsis sp. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. In addition, compounds 1–7 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 3 exhibited obvious anti-TMV activity with inhibition rate of 35.2% better than that of positive control (31.8%). The other compounds also showed potential anti-TMV activity with inhibition rates in the range of 18.6–25.7%, respectively. Graphical abstract

Source: Phytochemistry Letters - April 26, 2016 Category: Chemistry Source Type: research