Preclinical Research on Model Organisms to Predict Treatment Outcomes for Disorders Associated with Intellectual and Developmental Disabilities (R01)

Funding Opportunity PAR-16-215 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) encourages applications from institutions/ organizations addressing preclinical research in model organisms of neurodevelopmental disorders. Applications submitted to this FOA should propose to develop, validate, and/or calibrate outcome measures, surrogate markers, and biomarkers in model organisms that can inform and effectively translate to human clinical trials for individuals with intellectual and developmental disabilities (IDD). In addition, applications may propose to conduct rigorous, controlled and standardized preclinical animal trials designed for safety, toxicity, and efficacy prediction or to perform an independent validation of efficacy in animals prior to human clinical trials. The goal of this FOA is to accelerate and improve the preclinical testing of candidate treatments and therapeutic compounds in order to move promising new drug therapies into clinical trials. Potential applicants may also be interested in the FOA PAR-16-216, Outcome Measures For Use In Treatment Trials of Individuals with Intellectual and Developmental Disabilities.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding