Effect of scCO2 sorption capacity on the total amount of borage oil loaded by scCO2 impregnation/deposition into a polyurethane-based wound dressing

Publication date: September 2016 Source:The Journal of Supercritical Fluids, Volume 115 Author(s): C.V. da Silva, V.J. Pereira, P.T.V. Rosa, E.C.M. Cabral-Albuquerque, S.A.B. Vieira de Melo, G.M.N. Costa, A.M.A. Dias, H.C. de Sousa, M.E.M. Braga In this work, experimental equilibrium solubility data of scCO2 in polyurethane (PUR) foam (scCO2 sorption capacity) was measured by a gravimetric method for different isotherms (308, 318 and 328K), scCO2 densities (650, 750 and 850kgm−3) and scCO2 exposure times (0.5, 2, 4, 8 and 16h). Sorption data and CO2 desorption coefficients were estimated from desorption curves that were modeled using both numerical and analytical solution of Fick’s second law, with deviations below 10% in both cases. The influence of scCO2 sorption capacity on the amount of borage oil impregnated/deposited into the PUR foamed matrix was studied for selected pressure and temperature conditions and based on scCO2 sorption data. Results showed that the highest solubility of scCO2 in PUR (∼70%) was achieved at the lowest temperature and highest solvent density studied (308K and 850kgm−3) while the highest borage oil loaded yield was observed at the highest temperature and solvent density studied (328K and 850kgm−3), meaning that the impregnation/deposition process is controlled by the solubility of borage oil in scCO2. All the compounds present in borage oil (and which are detected by HPLC) were successfully loaded into the PUR mat...

Source: The Journal of Supercritical Fluids - April 24, 2016 Category: Chemistry Source Type: research