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Skeletal Health Part 1: Bone Health in the Cancer SettingSkeletal Health Part 1: Bone Health in the Cancer Setting

Bone metastases and cancer therapy induced osteoporosis are commonly seen in patients with cancer. Read how to best manage bone health in cancer patients. Urologic Nursing
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Urology Journal Article Source Type: news

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Abstract Boron is an essential mineral that plays an important role in several biological processes. Boron is required for growth of plants, animals, and humans. There are increasing evidences of this nutrient showing a variety of pleiotropic effects, ranging from anti-inflammatory and antioxidant effects to the modulation of different body systems. In the past few years, the trials showed disease-related polymorphisms of boron in different species, which has drawn attention of scientists to the significance of boron to health. Low boron profile has been related with poor immune function, increased risk of mortali...
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research
Researchers have identified a new regulator of vitamin D metabolism that could be targeted to reduce the risk of osteoporosis in men undergoing prostate cancer therapy, according to a study published in theJournal of Molecular Endocrinology.Medical Xpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Publication date: 24 March 2018 Source:Inorganica Chimica Acta, Volume 473 Author(s): Aya A. Fathy, Ian S. Butler, Mohamed Abd Elrahman, Bertrand J. Jean-Claude, Sahar I. Mostafa Bisphosphonates represent a significant subclass of phosphonates, organophosphorus compounds. Nitrogenous bisphosphonates have been used in the treatment of bone-related disease including osteoporosis and cancer therapies. The new palladium(II)-alendronate (H2Ald), {[Pd(Ald)(H2O)2] and [Pd2(bpy)2(Ald-2H)]} complexes were synthesized and characterized using IR, NMR (1H, 13C, 31P), UV–visible, mass spectra, elemental analysis, molar conductiv...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
The current standard treatments for cancer, chemotherapy and radiotherapy, are quite unpleasant and harmful; no-one would voluntarily undergo them given a better alternative. In fact, treatment makes people physically older, accelerating the processes of aging. There is evidence to suggest that this is due to an added burden of senescent cells. Cells become senescent in response to damage or a toxic environment, and there is plenty of that going around in any earnest attempt to treat cancer with radiation or chemical agents; in fact, many cancer therapies are intended to aggressively induce senescence in tumor cells. ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Abstract Low vitamin D status is considered as a risk factor for breast cancer and has prognostic significance. Furthermore, vitamin D deficiency increases after adjuvant cancer therapy, which alters bone metabolism increasing the risk of osteoporosis. It is now postulated that vitamin D supplementation in breast cancer treatment delays the recurrence of cancer thereby extending survival. We evaluated the impact of calcitriol and its low-calcemic analogs, PRI‑2191 and PRI‑2205, on the tumor growth, angiogenesis, and metastasis of 4T1 mouse mammary gland cancer. Gene expression analysis related t...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Tags: Int J Oncol Source Type: research
In this study, we demonstrate that irrespective of the derivation of CD8+ CD45RA+CD27- T cells, these primed cells exhibit a unique highly inflammatory secretory profile characteristic of the SASP, and we also provide evidence that ADAM28 can be used as a functional marker of senescence in CD8+ T cells. Furthermore, we show that the secretory phenotype in CD8+ CD45RA+CD27- T cells is controlled through p38 MAPK signalling, which contributes to age-associated inflammation. Patient Paid Clinical Studies are a Good Plan for Rejuvenation Therapies https://www.fightaging.org/archives/2017/10/patient-paid-clinical-st...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Persistent activation of IL-6/STAT3 signaling pathway has been frequently detected in human cancer including breast cancer, colon cancer, and multiple myeloma. IL-6/STAT3 can be a promising target for cancer prevent and treatment. However, few STAT3 inhibitors with high efficiency, specificity and safety is available for present clinical cancer therapy. Evista (Raloxifene·HCl) is known as selective estrogen receptor modulator which has been used for the prevention and treatment of osteoporosis and was approved for reducing the risk of invasive breast cancer. Our previous study found that Raloxifene...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
Summary The cure rate of testicular cancer exceeds 95%, but testicular cancer survivors (TCS) are at increased risk of hypogonadism (HG). It has been suggested that TCS have reduced bone mineral density (BMD), but it is unclear whether this is related to HG or a direct effect of cancer therapy. The aim of this study was to evaluate whether TCS have decreased BMD, and if BMD is related to HG and/or the cancer treatment given. We investigated 91 TCS (mean age at diagnosis: 31 years; mean 9.3 years follow‐up) and equal number of age matched controls (mean age at inclusion 40.3 years and 41.2 years, respe...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
BY JOHN IRVINE We asked THCB’s editors and bloggers for their reactions to Friday’s news. Here are their reactions. DANIEL STONE, MD The late UCLA Professor Richard Brown, once commented that the Clinton healthcare initiative failed because the status quo was everyone’s second choice. Some of that logic applies to today’s failure to vote on the AHCA. Additionally, no one ever lost money betting against the rollback of an established entitlement program. The Republicans opponents of the ACA have not yet faced the fact that the reason coverage is so expensive is because the care is so expensive. You ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized John Irvine Source Type: blogs
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