Negative sestamibi scan for primary hyperparathyroidism can mean no referral or surgery

BALTIMORE – In the treatment of primary hyperparathyroidism, clinical guidelines recommend using sestamibi scan for localizing adenoma, but increasingly endocrinologists are using sestamibi results...
Source: Clinical Endocrinology News - Category: Endocrinology Source Type: news

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CONCLUSION: The focused parathyroidectomy under SCB yielded a good result with concordant preoperative Sestamibi and ultrasound findings. PMID: 30010261 [PubMed - in process]
Source: South African Journal of Surgery - Category: Surgery Tags: S Afr J Surg Source Type: research
ConclusionDecreased level of 25-OH vitamin D is present in more than half of cholestatic patients, and is correlated positively to serum calcium. Decreased BMD was present in more than half of studied cholestatic patients correlated to the low serum calcium rather than the vitamin D level. The decreased BMD and the dental affection in cholestatic children is related to the level of hyperbilirubinemia.
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
AbstractSummaryIncreased levels of parathyroid hormone (PTH) may have adverse effects on bone health. In a cross-sectional design, we investigated this hypothesis among 102 postmenopausal vitamin D insufficient women. Elevated PTH was associated with altered bone geometry, decreased bone mineral density in the spine, and increased bone turnover.IntroductionIn vitamin D insufficiency, elevated parathyroid hormone (PTH) levels may contribute to adverse effect on bone. We assessed effects of PTH responses to vitamin D insufficiency on bone metabolism, density, and geometry.MethodsUsing a cross-sectional design, we investigate...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
rk L Abstract Context: Some patients with primary hyperparathyroidism (PHPT) develop renal calcifications. Investigation of urinary and non-urinary risk factors are essential. Objective: We aimed to study the prevalence and potential biochemical predictors of renal calcifications. Design: Nested case-control study. Settings: University Hospital. Patients or Other Participants: We identified 792 patients with PHPT from 2005-2015. We used biochemical data to validate the diagnosis of PHPT. Main Outcome Measures: The prevalence of renal calcifications defined as nephrolithiasis or nephrocalci...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Journal of Medical Imaging and Radiation Oncology, EarlyView.
Source: Australasian Radiology - Category: Radiology Authors: Source Type: research
1436Objectives:Preoperative ultrasonography and 99mTc-sestaMIBI are commonly used to localize abnormal parathyroid glands. When these procedures failed in the detection of lesions it is important to rely on another diagnostic imaging modalities. 18F-FDG and 11C-methionine have been studied, but are imperfect to detect abnormal parathyroid glands. We have evaluated the role of 18F-Fluorocholine (FCH) PET-CT in the detection of parathyroid adenoma in patients with primary hyperparathyroidism with negative or inconclusive ultrasound and Tc99m-sestaMIBI SPECT-CT prior to radioguided surgery (ROLL guided by ultrasound) based on...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Head and Neck Posters Source Type: research
Conclusion: Adding SPECT/CT to DSPS significantly reduced equivocal results by either confirming or excluding the presence of adenoma based on its location, decreased false positive results due to underlying thyroid lesions and achieved definite diagnosis with no need for delayed images in 95% of cases. Addition of delayed phase may only be considered in patients with negative or equivocal results after early SPECT/CT.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine/Neuroendocrine Posters Source Type: research
1326Objectives: To assess the utility of early dynamic PET/CT with 18F-Fluorocholine (FCH) in imaging of parathyroid adenomas. Methodology:This was a prospective cohort based study. 12 patients with clinical and biochemical evidence of primary hyperparathyroidism and positive 99m Tc-Sestamibi scan were included. Dynamic 18
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine/Neuroendocrine Posters Source Type: research
Conclusion: Parathyroid 4D CT provides better preoperative localization compared to sestamibi SPECT/CT in patients with solitary adenomas and multigland disease. The combination of the two modalities does not result in improved diagnostic accuracy compared to either modality alone. 4D CT and sestamibi SPECT/CT image of a left upper parathyroid adenoma.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Thyroid and Parathyroid Imaging Source Type: research
Conclusion: In this retrospective study, 99mTc-MIBI multi-temporal SPECT and SPECT/CT images may provide helps for localization of the hyperparathyroidism glands accurately.It results that it is not necessary to perform delay imaging for autograft area.Future prospective studies in larger patient groups are desirable for confirming our findings.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Thyroid and Parathyroid Imaging Source Type: research
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